A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial

Hirofumi Nakano, Hiromi Hamada, Masaaki Nakayama, Noritomo Itami, Ryoichi Nakazawa, Sadayoshi Ito

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DOI: 10.1093/ndt/gfq196 DOI is the universal ID for this study.

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Abstract:

Background: Chronic inflammation in haemodialysis (HD) patients indicates a poor prognosis. However, therapeutic approaches are limited. Hydrogen gas (H(2)) ameliorates oxidative and inflammatory injuries to organs in animal models. We developed an HD system using a dialysis solution with high levels of dissolved H(2) and examined the clinical effects.

Methods: Dialysis solution with H(2) (average of 48 ppb) was produced by mixing dialysate concentrates and reverse osmosis water containing dissolved H(2) generated by a water electrolysis technique. Subjects comprised 21 stable patients on standard HD who were switched to the test HD for 6 months at three sessions a week.

Results: During the study period, no adverse clinical signs or symptoms were observed. A significant decrease in systolic blood pressure (SBP) before and after dialysis was observed during the study, and a significant number of patients achieved SBP <140 mmHg after HD (baseline, 21%; 6 months, 62%; P < 0.05). Changes in dialysis parameters were minimal, while significant decreases in levels of plasma monocyte chemoattractant protein 1 (P < 0.01) and myeloperoxidase (P < 0.05) were identified. Conclusions: Adding H(2) to haemodialysis solutions ameliorated inflammatory reactions and improved BP control. This system could offer a novel therapeutic option for control of uraemia.


Publish Year 2010
Country Japan
Rank Positive
Journal Nephrology, Dialysis, and Transplantation
Primary Topic Kidney
Secondary TopicHaemodialysis
Model Human
Tertiary TopicOxidative Stress
Vehicle Water (Electrolysis)
pH Alkaline
Application Injection
Comparison
Complement