The potential cardioprotective effects of hydrogen in irradiated mice

Li Qian, Fei Cao, Jianguo Cui, Yicun Wang, Yuecheng Huang, Yunhai Chuai, Luqian Zaho, Hao Jiang, Jianming Cai

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DOI: 10.1269/jrr.10093 DOI is the universal ID for this study.

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Most ionizing radiation-induced damage is caused by hydroxyl radicals, and the selective reduction of hydroxyl by hydrogen in vitro has been demonstrated previously. Irradiation of the heart can cause chronic cardiac disease. This study was designed to test the hypothesis that hydrogen-rich water (pure water saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ionizing irradiation injury in mice. In this paper, we demonstrate that hydrogen can protect myocardium degeneration from radiation-induced injury, decrease myocardium malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG) levels, and increase myocardium endogenous antioxidants in vivo. We suggest that hydrogen has a cardioprotective effect against radiation induced injury.

Publish Year 2010
Country China
Rank Positive
Journal Journal of Radiation Research
Primary Topic Heart
Secondary Topic Radioprotection
Model Mouse
Tertiary Topic Gamma Radiation
Vehicle Water (Dissolved)
pH Neutral
Application Ingestion