Anti-diabetic effects of electrolyzed reduced water in streptozotocin-induced and genetic diabetic mice

Mi Kim, Hye Kyung Kim

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DOI: 10.1016/j.lfs.2006.07.027 DOI is the universal ID for this study.

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Abstract:

Oxidative stress is produced under diabetic conditions and is likely involved in progression of pancreatic beta-cell dysfunction found in diabetes. Both an increase in reactive oxygen free radical species (ROS) and a decrease in the antioxidant defense mechanism lead to the increase in oxidative stress in diabetes. Electrolyzed reduced water (ERW) with ROS scavenging ability may have a potential effect on diabetic animals, a model for high oxidative stress. Therefore, the present study examined the possible anti-diabetic effect of ERW in two different diabetic animal models. The genetically diabetic mouse strain C57BL/6J-db/db (db/db) and streptozotocin (STZ)-induced diabetic mouse were used as insulin deficient type 1 and insulin resistant type 2 animal model, respectively. ERW, provided as a drinking water, significantly reduced the blood glucose concentration and improved glucose tolerance in both animal models. However, ERW fail to affect blood insulin levels in STZ-diabetic mice whereas blood insulin level was markedly increased in genetically diabetic db/db mice. This improved blood glucose control could result from enhanced insulin sensitivity, as well as increased insulin release. The present data suggest that ERW may function as an orally effective anti-diabetic agent and merit further studies on its precise mechanism.

Publish Year 2006
Country Korea
Rank Positive
Journal Life Sciences
Primary Topic Pancreas
Secondary Topic Diabetes
Model Mouse
Tertiary Topic Glucose Metabolism
Vehicle Water (Electrolysis)
pH Alkaline
Application Ingestion
Comparison
Complement