Anti-diabetic effects of electrolyzed reduced water in streptozotocin-induced and genetic diabetic mice
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DOI:
10.1016/j.lfs.2006.07.027
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Abstract:
Oxidative stress is produced under diabetic conditions and is likely involved in progression of pancreatic beta-cell dysfunction found in diabetes. Both an increase in reactive oxygen free radical species (ROS) and a decrease in the antioxidant defense mechanism lead to the increase in oxidative stress in diabetes. Electrolyzed reduced water (ERW) with ROS scavenging ability may have a potential effect on diabetic animals, a model for high oxidative stress. Therefore, the present study examined the possible anti-diabetic effect of ERW in two different diabetic animal models. The genetically diabetic mouse strain C57BL/6J-db/db (db/db) and streptozotocin (STZ)-induced diabetic mouse were used as insulin deficient type 1 and insulin resistant type 2 animal model, respectively. ERW, provided as a drinking water, significantly reduced the blood glucose concentration and improved glucose tolerance in both animal models. However, ERW fail to affect blood insulin levels in STZ-diabetic mice whereas blood insulin level was markedly increased in genetically diabetic db/db mice. This improved blood glucose control could result from enhanced insulin sensitivity, as well as increased insulin release. The present data suggest that ERW may function as an orally effective anti-diabetic agent and merit further studies on its precise mechanism.| Publish Year | 2006 |
|---|---|
| Country | South Korea |
| Rank | Positive |
| Journal | Life Sciences |
| Primary Topic | Pancreas |
| Secondary Topic | Diabetes |
| Model | Mouse |
| Tertiary Topic | Glucose Metabolism |
| Vehicle | Water (Electrolysis) |
| pH | Alkaline |
| Application | Ingestion |
| Comparison | |
| Complement |