Hydrogen Water Reduces Eczema Symptoms in Mice Study
- Authors
- Rosa Mistica C. Ignacio, Hyun-Suk Kwak, Young-Uk Yun, Ma. Easter Joy V. Sajo, Yang-Suk Yoon, Cheol-Su Kim, Soo-Ki Kim, Kyu-Jae Lee
- Journal
- Evidence-Based Complementary and Alternative Medicine
- Year
- 2013
- DOI
- 10.1155/2013/538673
- Study Type
- Mouse
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- South Korea
- Health Condition
- Atopic Dermatitis
- Body System
- Integumentary
TL;DR
Drinking hydrogen water (HW) may help reduce the severity of atopic dermatitis (AD), an inflammatory skin condition, by affecting immune responses in mice.
Key Finding
Mice with allergy-induced atopic dermatitis that drank hydrogen water showed significantly reduced levels of pro-inflammatory chemicals (TNF-α, IL-10, IL-12p70, and GM-CSF) in their blood compared to mice drinking regular water.
Summary
Researchers gave mice with allergy-induced skin inflammation (atopic dermatitis) either hydrogen water or regular water for 25 days. They measured inflammatory chemicals in the mice's blood and found that those drinking hydrogen water had lower levels of several inflammation-related substances compared to the regular water group. This suggests hydrogen water may help reduce the immune system overreaction that causes this type of skin condition.
Practical Takeaway
This is early-stage research in mice only, so it cannot yet tell us whether hydrogen water would help people with atopic dermatitis. The study suggests hydrogen water may influence immune responses related to skin inflammation, but human clinical trials would be needed to determine if these effects translate to actual health benefits in people with this condition.
Abstract
Hydrogen water (HW) produced by electrolysis of water has characteristics of extremely low oxidation-reduction potential (ORP) value and high dissolved hydrogen (DH). It has been proved to have various beneficial effects including antioxidant and anti-inflammatory effects; however, HW effect on atopic dermatitis (AD), an inflammatory skin disorder, is poorly documented. In the present study, we examined the immunological effect of drinking HW onDermatophagoides farinae-induced AD-like skin in NC/Nga mice. Mice were administered with HW and purified water (PW) for 25 days. We evaluated the serum concentration of pro-inflammatory (TNF-α), Th1 (IFN-γ, IL-2, and IL-12p70), Th2 (IL-4, IL-5, and IL-10), and cytokine expressed by both subsets (GM-CSF) to assess their possible relationship to the severity of AD. The serum levels of cytokines such as IL-10, TNF-α, IL-12p70, and GM-CSF of mice administered with HW was significantly reduced as compared to PW group. The results suggest that HW affects allergic contact dermatitis through modulation of Th1 and Th2 responses in NC/Nga mice. This is the first note on the drinking effect of HW on AD, clinically implying a promising potential remedy for treatment of AD.