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Studies Found: 1335

SPINE - PARAPLEGIA

Beneficial effects of hydrogen gas against spinal cord ischemia-reperfusion injury in rabbits

Year Published: 2011

Recently, hydrogen gas (H₂) is reported to be a new therapeutic agent in organ damage induced by ischemia-reperfusion (I/R). The present study was designed to investigate the beneficial effects of H₂ against spinal cord I/R injury and its associated mechanisms. Spinal cord ischemia was induced by infrarenal aortic occlusion for 20 min in male New Zealand white rabbits. Treatment with 1%, 2% or ...
KIDNEY - METABOLIC SYNDROME

Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Lepr cp /NDmcr rat – A metabolic ...

Year Published: 2011

Hydrogen (H2), a potent free radical scavenger, selectively reduces the hydroxyl radical, which is the most cytotoxic of the reactive oxygen species (ROS). An increase in oxygen free radicals induces oxidative stress, which is known to be involved in the development of metabolic syndrome. Therefore, we investigated whether hydrogen-rich water (HRW) affects metabolic abnormalities in the metabolic ...
HEART - SLEEP APNEA

Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in ...

Year Published: 2011

Sleep apnea syndrome increases the risk of cardiovascular morbidity and mortality. We previously reported that intermittent hypoxia increases superoxide production in a manner dependent on nicotinamide adenine dinucleotide phosphate and accelerates adverse left ventricular (LV) remodeling. Recent studies have suggested that hydrogen (H(2)) may have an antioxidant effect by reducing hydroxyl ...
MUSCLE - DISUSE ATROPHY

Effect of Molecular Hydrogen Saturated Alkaline Electrolyzed Water on Disuse Muscle Atrophy in ...

Year Published: 2011

The objectives of this paper were to determine the level of oxidative stress in atrophied gastrocnemius, and to verify the effect of molecular hydrogen (H2) saturated alkaline electrolyzed water (HSW) on gastrocnemius atrophy by modifying the redox status, indicated by 8-hydroxy-2'-deoxyguanosine (8-OHdG), malondialdehyde (MDA), and superoxide dismutase (SOD)-like activity. Female Wistar rats were ...
BONE - ROS-SCAVENGING

Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene ...

Year Published: 2011

Background: Molecular hydrogen (H2) functions as an extensive protector against oxidative stress, inflammation and allergic reaction in various biological models and clinical tests; however, its essential mechanisms remain unknown. H2 directly reacts with the strong reactive nitrogen species peroxynitrite (ONOO-) as well as hydroxyl radicals (•OH), but not with nitric oxide radical (NO•). We ...
BRAIN - SURGERY/TRANSPLANTATION

Hydrogen is neuroprotective against surgically induced brain injury

Year Published: 2011

Neurosurgical operations cause unavoidable damage to healthy brain tissues. Direct surgical injury as well as surgically induced oxidative stress contributes to the subsequent formation of brain edema. Therefore, we tested the neuroprotective effects of hydrogen (H2) in an established surgical brain injury (SBI) model in rats. Adult male Sprague - Dawley rats (weight 300-350g) were divided into ...
LUNG - LUNG INJURY

Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model

Year Published: 2011

Hydrogen has been reported to selectively quench detrimental reactive oxygen species, particularly hydroxyl radical, and to prevent myocardial or hepatic ischemia/reperfusion injury in multiple models. The aim of this study is to investigate whether hydrogen protects against severe burn-induced acute lung injury in rats. Rats were divided into four groups: sham plus normal saline, burn injury plus ...
LUNG - UPPER RESPIRATORY TRACT INFECTION

Effect of acid-electrolyzed water on bacteria of upper respiratory tract infections

Year Published: 2011

People are aware of the importance of health, especially the effect of electrolyzed water. So the market for electrolyzed water-related equipment has increased recently. People only know the importance of alkaline-electrolyzed water to health, but the effects of acid-electrolyzed water are not as well known. In this study, we evaluated the characteristics and functions of acid-electrolyzed water ...
TESTES - RADIOPROTECTION

Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing ...

Year Published: 2011

Our recent studies suggest that H2 (hydrogen) has a potential as a novel radioprotector without known toxic side effects. The present study was designed to examine the underlying radioprotective mechanism of H2 and its protective role on irradiated germ cells. Produced by the Fenton reaction and radiolysis of H2O, hydroxyl radicals (•OH) were identified as the free radical species that were ...
INTESTINE - INTESTINAL INJURY

The Effects of Hydrogen-Rich Saline on the Contractile and Structural Changes of Intestine Induced ...

Year Published: 2011

Background: Hydrogen has been considered as a novel antioxidant that prevents injuries resulted from ischemia-reperfusion (I/R) injury in various tissues. The study was designed to determine the effect of hydrogen-rich saline on the smooth muscle contractile response to KCl, and on epithelial proliferation and apoptosis of intestine subjected to I/R. Methods: Intestinal I/R injury was induced in ...
BRAIN - STROKE

Hydrogen Gas Reduced Acute Hyperglycemia-Enhanced Hemorrhagic Transformation In A Focal Ischemia Rat ...

Year Published: 2011

Hyperglycemia is one of the major factors for hemorrhagic transformation after ischemic stroke. In this study, we tested the effect of hydrogen gas on hemorrhagic transformation in a rat focal cerebral ischemia model. Sprague-Dawley rats (n=72) were divided into the following groups: sham; sham treated with hydrogen gas (H(2)); Middle Cerebral Artery Occlusion (MCAO); and MCAO treated with H(2) ...
HEART - CARDIOVASCULAR DISEASE

Intravenous low redox potential saline attenuates FeCl3-induced vascular dysfunction via ...

Year Published: 2011

Exaggerated reactive oxygen species (ROS) may contribute to vascular injury by the enhancement of CX3CL1, intercellular adhesion molecule-1 (ICAM-1), and pro-apoptotic p53 expression. Reduced water with safely antioxidant activity may protect vascular tissue against oxidative injury. We established reduced water (RW) by using a modified magnesium alloy and evaluated the effects of an RW-made ...
BRAIN - BRAIN INJURY

Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema ...

Year Published: 2012

Background: Increasing experimental and clinical data indicate that early brain injury (EBI) after subarachnoid hemorrhage (SAH) largely contributes to unfavorable outcomes, and it has been proved that EBI following SAH is closely associated with oxidative stress and brain edema. The present study aimed to examine the effect of hydrogen, a mild and selective cytotoxic oxygen radical scavenger, on ...
HEART - ATHEROSCLEROSIS

Administration of hydrogen-saturated saline decreases plasma low-density lipoprotein cholesterol ...

Year Published: 2012

Hydrogen (dihydrogen; H(2)) has an antiatherosclerotic effect in apolipoprotein (apo) E knockout mice. The goals of this study were to further characterize the effects of H(2) on the content, composition, and biological activities of plasma lipoproteins in golden hamsters. Plasma analysis by enzymatic method and fast protein liquid chromatography showed that 4-week intraperitoneal injection of ...
INTESTINE - SURGERY/TRANSPLANTATION

Hydrogen-Enriched Preservation Protects the Isogeneic Intestinal Graft and Amends Recipient Gastric ...

Year Published: 2011

Inhaled hydrogen gas exerts antioxidant and anti-inflammatory effects in rat intestinal transplantation. Here, we investigated whether ex vivo donor organ treatment with dissolved hydrogen would prevent intestinal graft injury. Isogeneic intestinal transplantation was performed in Lewis rats with vascular flush, luminal preservation, and cold graft storage in nitrogen-bubbled (SITxN2) or ...
BRAIN - SEPSIS

Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats ...

Year Published: 2012

Background: Sepsis is associated with high morbidity and mortality, and survivors can present with cognitive dysfunction. The present study was performed to investigate the effects of hydrogen-rich saline (HRS) on oxidative stress in the brain, cognitive dysfunction, and mortality in a rat model of sepsis. Methods: A rat model of sepsis was induced by cecal ligation and puncture. Physiologic ...
EAR - HEARING LOSS

Hydrogen-rich saline alleviates experimental noise-induced hearing loss in guinea pigs

Year Published: 2012

To examine the efficiency of hydrogen-rich saline in the treatment of intensive noise-induced cochlear injury. Forty guinea pigs were assigned to one of four groups: HS+NOISE (i.p. injection hydrogen-rich saline), NS+NOISE (i.p. injection normal saline), NOISE ALONE (noise control), and NO TREATMENT (normal control) groups. The HS+NOISE, NS+NOISE, and NOISE ALONE groups were exposed to intensive ...
BRAIN - BRAIN INJURY

Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in ...

Year Published: 2012

Hydrogen gas has been demonstrated to neutralize free radicals and reduce oxidative stress recently. Our objective was to determine the therapeutic effect of H2 inhalation and its antioxidative activity on early brain injury after subarachnoid hemorrhage. Controlled in vivo laboratory study. Animal research laboratory. One hundred thirty-seven adult male Sprague-Dawley rats weighing 280-350 g. ...
HEART - HIGH BLOOD PRESSURE

Chronic hydrogen-rich saline treatment attenuates vascular dysfunction in spontaneous hypertensive ...

Year Published: 2012

In hypertensive patients, increased oxidative stress is thought to be one important cause of vascular dysfunction. Recently, it has been suggested that hydrogen exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radical and peroxynitrite, the most cytotoxic chemicals of reactive oxygen species (ROS). Herein, we investigated the protective effect of chronic treatment with ...
HEART - HIGH BLOOD PRESSURE

Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular ...

Year Published: 2012

In hypertensive animals and patients, oxidative stress represents the primary risk factor for progression of left ventricular hypertrophy. Recently, it has been demonstrated that hydrogen, as a novel antioxidant, can selectively reduce hydroxyl radicals and peroxynitrite anion to exert therapeutic antioxidant activity. In the current study, we explored the effect of chronic treatment with ...
WHOLE BODY - IMMUNE DYSFUNCTION

The Anti-inflammation effects of hydrogen saline in LPS activated macrophages and carrageenan ...

Year Published: 2012

Oxidative stress is thought to play an important role in the pathogenesis of inflammation. Recent studies have found that hydrogen gas has the effect of eliminating free radicals. Whether hydrogen saline (more convenient to be used than hydrogen gas) has the anti-inflammation effect or not is still unknown. Carrageenan-induced paw oedema and LPS-activated macrophages are studied in this article. ...
WHOLE BODY - CANCER

Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis

Year Published: 2012

Background: Radiation often causes depletion of immunocytes in tissues and blood, which results in immunosuppression. Molecular hydrogen (H2) has been shown in recent studies to have potential as a safe and effective radioprotective agent through scavenging free radicals. This study was designed to test the hypothesis that H2 could protect immunocytes from ionizing radiation (IR). ...
HEART - HEART ATTACK

H2 Mediates Cardioprotection Via Involvements of KATP Channels and Permeability Transition Pores of ...

Year Published: 2012

Inhalation of hydrogen (H(2)) gas has been shown to limit infarct size following ischemia-reperfusion injury in rat hearts. However, H(2) gas-induced cardioprotection has not been tested in large animals and the precise cellular mechanism of protection has not been elucidated. We investigated whether opening of mitochondrial ATP-sensitive K+ channels (mK(ATP)) and subsequent inhibition of ...
WHOLE BODY - SEPSIS

Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis

Year Published: 2012

Sepsis is the most common cause of death in intensive care units. Some studies have found that hyperoxia may be beneficial to sepsis. However, the clinical use of hyperoxia is hindered by concerns that it could exacerbate organ injury by increasing free radical formation. Recently, it has been suggested that molecular hydrogen (H2) at low concentration can exert a therapeutic antioxidant activity ...
EYE - DIABETES

Protective Effects of Hydrogen Saline on Diabetic Retinopathy in a Streptozotocin-Induced Diabetic ...

Year Published: 2012

Diabetic retinopathy is the leading cause of blindness in the working population of the developed countries and also a significant cause of blindness in the elderly. This study aimed at examining the protective effect of H(2) saline on diabetic retinopathy in a streptozotocin-induced diabetic rat model. Sprague-Dawley male rats were divided into 3 groups as follows: (1) nondiabetic control group ...