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Studies Found: 1335

SKIN - PERMEABILITY

Effect of several electrolyzed waters on the skin permeation of lidocaine, benzoic Acid, and ...

Year Published: 2009

The effects of several electrolyzed waters were evaluated on the permeation of model base, acid and non-ionized compounds, lidocaine (LC), benzoic acid (BA), and isosorbide mononitrate (ISMN), respectively, through excised hairless rat skin. Strong alkaline-electrolyzed reducing water (ERW) enhanced and suppressed the skin permeation of LC and BA, respectively, and it also increased the skin ...
LUNG - ASTHMA

Molecular hydrogen suppresses FcεRI-mediated signal transduction and prevents degranulation of mast ...

Year Published: 2009

Molecular hydrogen ameliorates oxidative stress-associated diseases in animal models. We found that oral intake of hydrogen-rich water abolishes an immediate-type allergic reaction in mice. Using rat RBL-2H3 mast cells, we demonstrated that hydrogen attenuates phosphorylation of the FcεRI-associated Lyn and its downstream signal transduction, which subsequently inhibits the NADPH oxidase activity ...
INTESTINE - INFLAMMATORY BOWEL DISEASE

Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate

Year Published: 2009

By its antioxidant effect, molecular hydrogen gas (H2) was reported to protect organs from tissue damage induced by ischemia reperfusion. To evaluate its anti-inflammatory effects, we established a mouse model of human inflammatory bowel disease (IBD) by supplying mice with water containing (1) dextran sodium sulfate (DSS) (5%), (2) DSS (5%) and H2, or (3) H2 only ad libitum up to 7 days. At ...
LIVER - AUTOIMMUNE

Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis

Year Published: 2009

It is well known that some intestinal bacteria, such as Escherichia coli, can produce a remarkable amount of molecular hydrogen (H(2)). Although the antioxidant effects of H(2) are well documented, the present study examined whether H(2) released from intestinally colonized bacteria could affect Concanavalin A (ConA)-induced mouse hepatitis. Systemic antibiotics significantly decreased the level ...
BRAIN - PARKINSON'S DISEASE

Hydrogen in drinking water reduces dopaminergic neuronal loss in the ...

Year Published: 2009

It has been shown that molecular hydrogen (H(2)) acts as a therapeutic antioxidant and suppresses brain injury by buffering the effects of oxidative stress. Chronic oxidative stress causes neurodegenerative diseases such as Parkinson's disease (PD). Here, we show that drinking H(2)-containing water significantly reduced the loss of dopaminergic neurons in PD model mice using both acute and chronic ...
KIDNEY - KIDNEY FAILURE

Ionized Alkaline Water: New Strategy for Management of Metabolic Acidosis in Experimental Animals

Year Published: 2009

Metabolic acidosis can occur as a result of either the accumulation of endogenous acids or loss of bicarbonate from the gastrointestinal tract or the kidney, which represent common causes of metabolic acidosis. The appropriate treatment of acute metabolic acidosis has been very controversial. Ionized alkaline water was not evaluated in such groups of patients in spite of its safety and reported ...
BRAIN - PARKINSON'S DISEASE

Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a ...

Year Published: 2009

Molecular hydrogen serves as an antioxidant that reduces hydroxyl radicals, but not the other reactive oxygen and nitrogen species. In the past year, molecular hydrogen has been reported to prevent or ameliorate eight diseases in rodents and one in human associated with oxidative stress. In Parkinson's disease, mitochondrial dysfunction and the associated oxidative stress are major causes of ...
SKIN - ENVIRONMENTAL POLLUTION

Suppressive effect of electrolyzed reduced water on the paraben-induced DNA damage in human dermal ...

Year Published: 2010

Parabens have been widely used as preservatives in cosmetics due to the presumed low toxicity and long history of safe use. However, recent studies have shown the potent toxicity of parabens. In order to know if electrolyzed reduced water could suppress the oxidative DNA damage of HDF cell by methylparaben, one of the frequently used parabens, we performed comet assay in this study. As a result, ...
LUNG - DIVING

Saturated hydrogen saline protects the lung against oxygen toxicity

Year Published: 2010

Exposure to high oxygen concentrations leads to acute lung injury, including lung tissue and alveolar edema formation, congestion, intra-alveolar hemorrhage, as well as endothelial and epithelial cell apoptosis or necrosis. Several studies have reported that molecular hydrogen is an efficient antioxidant by gaseous rapid diffusion into tissues and cells. Moreover, consumption of water with ...
KIDNEY - HIGH BLOOD PRESSURE

Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal ...

Year Published: 2010

Hydrogen (H(2)) reportedly produces an antioxidative effect by quenching cytotoxic oxygen radicals. We studied the biological effects of water with dissolved H(2) on ischemia-induced cardio-renal injury in a rat model of chronic kidney disease (CKD). Dahl salt-sensitive rats (7 weeks old) were allowed ad libitum drinking of filtered water (FW: dissolved H(2), 0.00 ± 0.00 mg/L) or water with ...
WHOLE BODY - AGING

Electrolyzed Reduced Water Prolongs Caenorhabditis elegans’ Lifespan

Year Published: 2010

Electrolyzed reduced water (ERW) has been reported to scavenge intracellular reactive oxygen species (ROS) and improve oxidative stress-related diseases. A new culture method using water medium for Caenorhabditis elegans (C.elegans) was developed in order to elucidate the effects of ERW on the lifespan of nematode. ERW significantly extended the lifespan of C. elegans and alleviated the ROS Level ...
WHOLE BODY - AGING

Extension of the lifespan of Caenorhabditis elegans by the use of electrolyzed reduced water

Year Published: 2010

Electrolyzed reduced water (ERW) has attracted much attention because of its therapeutic effects. In the present study, a new culture medium, which we designated Water medium, was developed to elucidate the effects of ERW on the lifespan of Caenorhabditis elegans. Wild-type C. elegans had a significantly shorter lifespan in Water medium than in conventional S medium. However, worms cultured in ...
WHOLE BODY - SEPSIS

Effects of hydrogen gas inhalation on serum high mobility group box 1 levels in severe septic mice

Year Published: 2010

To investigate the effect of hydrogen gas inhalation on survival rate and serum high mobility group box 1 (HMGB1) levels in severe septic mice. Severe sepsis was induced by cecal ligation and puncture (CLP) operation in mice.A total of 248 mice were randomly divided into four groups: sham operation group (sham), sham operation with hydrogen gas inhalation group (sham+H2), severe CLP group (severe ...
WHOLE BODY - SEPSIS

Hydrogen Gas Improves Survival Rate and Organ Damage in Zymosan-Induced Generalized Inflammation ...

Year Published: 2010

Sepsis/multiple organ dysfunction syndrome is the leading cause of death in critically ill patients. Recently, it has been suggested that hydrogen gas (H2) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radical (•OH, the most cytotoxic reactive oxygen species). We have found that H2 inhalation significantly improved the survival rate and organ damage of septic mice ...
WHOLE BODY - SEPSIS

Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and ...

Year Published: 2010

Despite recent advances in antibiotic therapy and intensive care, sepsis is still considered to be the most common cause of death in intensive care units. Excessive production of reactive oxygen species plays an important role in the pathogenesis of sepsis. Recently, it has been suggested that molecular hydrogen (H2) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl ...
HEART - SURGERY/TRANSPLANTATION

Hydrogen-containing preservation solution relieves oxidative stress and inflammatory damage of rat ...

Year Published: 2010

Objective: To study the effect of hydrogen-containing preservation solution against oxidative stress and inflammatory damage of rat donor heart. Methods: Thirty-two SD rats were evenly randomized into four groups(n = 8) : control group (the hearts were protected by HTK solution), H1 group (hydrogen concentration was about 0.2 mmol/L in the HTK solution), H2 group (hydrogen concentration was about ...
EAR - HEARING LOSS

Hydrogen protects vestibular hair cells from free radicals

Year Published: 2010

Hydrogen gas effectively protected against the morphological and functional vestibular hair cell damage by reactive oxygen species (ROS). ROS are generally produced by oxidative stress. In the inner ear, ROS levels increase as a result of noise trauma and ototoxic drugs and induce damage. It is thus important to control ROS levels in the inner ear. The protective effects of hydrogen gas in ...
BRAIN - ROS-SCAVENGING

Hydrogen-related enhancement of in vivo antioxidant ability in the brain of rats fed coral calcium ...

Year Published: 2010

This study explored the effect of coral calcium hydride (CCH) on rat intrahippocampal antioxidant ability by measuring the PCAM nitroxide radical decay ratio when CCH was (a) co-perfused into the hippocampus and (b) fed orally to the rats for 4 weeks under a freely moving state. Estimation of the in vivo antioxidant effect was obtained by administration of the blood-brain barrier-permeable PCAM ...
WHOLE BODY - HYDROGEN BIOLOGY

Biological safety of neutral-pH hydrogen-enriched electrolyzed water upon mutagenicity, genotoxicity ...

Year Published: 2010

Hydrogen-dissolved water has been suggested to be effective for alleviating the oxidative stress. In the present study, neutral-pH hydrogen-enriched electrolyzed water (NHE-water; dissolved hydrogen: 0.90-1.14 parts per million [ppm]; oxido-reduced potential: -150 approximately -80 mV), which was prepared with a water-electrolysis apparatus equipped with a non-diaphragm cell and a highly ...
KIDNEY - SURGERY/TRANSPLANTATION

Hydrogen-rich saline solution attenuates renal ischemia-reperfusion injury

Year Published: 2010

Renal ischemia-reperfusion (I/R), an important cause of acute kidney injury, is unavoidable during various types of operations, including renal transplantation, surgical revascularization of the renal artery, partial nephrectomy, and treatment of suprarenal aortic aneurysms. Exacerbation of I/R injury is mediated by reactive oxygen species (ROS). A recent study has shown that hydrogen has ...
HEART - RADIOPROTECTION

The potential cardioprotective effects of hydrogen in irradiated mice

Year Published: 2010

Most ionizing radiation-induced damage is caused by hydroxyl radicals, and the selective reduction of hydroxyl by hydrogen in vitro has been demonstrated previously. Irradiation of the heart can cause chronic cardiac disease. This study was designed to test the hypothesis that hydrogen-rich water (pure water saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ...
WHOLE BODY - RADIOPROTECTION

Hydrogen-rich PBS protects cultured human cells from ionizing radiation-induced cellular damage

Year Published: 2010

Hydroxyl radicals play an important role in ionizing radiation-induced cellular damage, while hydrogen can selectively reduce hydroxyl radicals in vitro. This study was designed to test the hypothesis that hydrogen-rich PBS may be an effective radioprotective agent in vitro. Compared to cells pretreated without hydrogen, we demonstrated that treating cells with hydrogen-rich PBS before irradiation ...
WHOLE BODY - RADIOPROTECTION

Radioprotective effect of hydrogen in cultured cells and mice

Year Published: 2010

It has been demonstrated that hydrogen can selectively reduce hydroxyl and peroxynitrite in vitro. Since most of the ionizing radiation-induced cellular damage is caused by hydroxyl radicals, this study was designed to test the hypothesis that hydrogen may be an effective radioprotective agent. This paper demonstrates that treating cells with hydrogen before irradiation could significantly inhibit ...
SKIN - WOUND HEALING

The healing effect of electrolytic-reduction ion water on burn wounds

Year Published: 2010

We prepared a lotion using electrolytic-reduction ion water (ERI), and evaluated the healing effects of this lotion (ERI lotion) on burn wounds. Third degree burn wounds were induced in the mouse dorsal skin, and ERI lotion or physiological salt (PS) lotion was applied to the wounds from immediately after injury [ERI (+) group and ERI (-) group as a control group, respectively]. The burn wound ...
WHOLE BODY - DIABETES (TYPE II)

Anti-Diabetes Effects of Hita Tenryou-Sui Water®, a Natural Reduced Water

Year Published: 2010

It has been reported that a natural reduced water derived from a deep well in Japan (trademark, Hita Tenryousui water®; Nakanoshima, Hita city, Oita, Japan) scavenged intracellular reactive oxygen species (ROS) and protected a hamster pancreas β cell line HIT-T15 from oxidative damage by alloxan, a type 1 diabetes inducer. Here we demonstrated that the water also suppressed the fasted blood ...