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Studies Found: 1335

WHOLE BODY - EXCERCISE

Effect of Treadmill Exercise and Hydrogen-rich Water Intake on Serum Oxidative and Anti-oxidative ...

Year Published: 2013

The present study aimed to clarify changes of oxidative stress and antioxidative functions in treadmill-exercised Thoroughbred horses (n=5, 3 to 7 years old), using recently developed techniques for measurement of serum d-ROMs for oxidative stress, and BAP for antioxidative markers. Also, the effect of nasogastric administration of hydrogen-rich water (HW) or placebo water preceding the treadmill ...
HEART - SURGERY/TRANSPLANTATION

Hydrogen as additive of HTK solution fortifies myocardial preservation in grafts with prolonged cold ...

Year Published: 2013

Background: Recent evidences indicated that hydrogen (H2) can attenuate organ transplantation induced cold ischemia/reperfusion (I/R) injury if administrated perioperatively. In this study we evaluated whether administrating H2 during the prolonged cold ischemia stage by adding it to Histidine-Tryptophan-Ketoglutarate (HTK) solution fortifies preservation for cardiac grafts. Methods: One hundred ...
PERITONIUM - PERITONEAL DIALYSIS

Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel ...

Year Published: 2013

Background: Oxidative stress (OS) related to glucose degradation products such as methylglyoxal is reportedly associated with peritoneal deterioration in patients treated with peritoneal dialysis (PD). However, the use of general antioxidant agents is limited due to their harmful effects. This study aimed to clarify the influence of the novel antioxidant molecular hydrogen (H2) on peritoneal OS ...
WHOLE BODY - METABOLIC SYNDROME

Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients ...

Year Published: 2013

We have found hydrogen (dihydrogen; H2) has beneficial lipid-lowering effects in high-fat diet-fed Syrian golden hamsters. The objective of this study was to characterize the effects of H2-rich water (0.9-1.0 L/day) on the content, composition, and biological activities of serum lipoproteins on 20 patients with potential metabolic syndrome. Serum analysis showed that consumption of H2-rich water ...
BONE - SPACEFLIGHT

Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled ...

Year Published: 2013

Treatment with molecular hydrogen alleviates microgravity-induced bone loss through abating oxidative stress, restoring osteoblastic differentiation, and suppressing osteoclast differentiation and osteoclastogenesis. Introduction: Recently, it has been suggested that hydrogen gas exerts a therapeutic antioxidant activity by selectively reducing cytotoxic reactive oxygen species (ROS). The aim of ...
SKIN - RADIOPROTECTION

Atomic hydrogen surrounded by water molecules, H(H2O)m, modulates basal and UV-induced gene ...

Year Published: 2013

Recently, there has been much effort to find effective ingredients which can prevent or retard cutaneous skin aging after topical or systemic use. Here, we investigated the effects of the atomic hydrogen surrounded by water molecules, H(H2O)m, on acute UV-induced responses and as well as skin aging. Interestingly, we observed that H(H2O)m application to human skin prevented UV-induced erythema and ...
HEART - HEART ATTACK

Breathing Nitric Oxide plus Hydrogen Gas Reduces Ischemia-Reperfusion Injury and Nitrotyrosine ...

Year Published: 2013

Inhaled nitric oxide (NO) has been reported to decrease the infarct size in cardiac ischemia reperfusion (I-R) injury. However, reactive nitrogen species (RNS) produced by NO causes myocardial dysfunction and injury. Since H2 is reported to eliminate peroxynitrite, it was expected to reduce the adverse effects of NO. In mice, left anterior descending coronary artery ligation for 60 min followed by ...
WHOLE BODY - AGING

Electrolyzed-reduced water increases resistance to oxidative stress, fertility, and lifespan via ...

Year Published: 2013

Electrolyzed-reduced water (ERW) scavenges reactive oxygen species and is a powerful anti-oxidant. A positive correlation between oxidative stress and aging has been proved in many model organisms. In Caenorhabditis elegans, many long-lived mutants showed reduced fertility as a trade off against longevity phenotype. We aimed to study the effect of ERW on oxidative stress, fertility and lifespan of ...
BONE MARROW - SURGERY/TRANSPLANTATION

Administration of Hydrogen-Rich Saline Protects Mice From Lethal Acute Graft-Versus-Host Disease ...

Year Published: 2013

Allogeneic hematopoietic stem cell transplantation is a potentially curative therapy for many malignant and nonmalignant hematologic diseases. However, acute graft-versus-host disease (aGVHD) is a lethal complication of hematopoietic stem cell transplantation, which limits its application. Cytokines such as tumor necrosis factor-α and interleukin-6 play an extremely important role in the ...
INTESTINE - INTESTINAL INJURY

Protective effects of hydrogen-rich saline on necrotizing enterocolitis in neonatal rats

Year Published: 2013

Purpose: The aim of this study was to test the hypothesis that hydrogen-rich saline (HRS) might have protective effects on the development of necrotizing enterocolitis (NEC) in a neonatal rat model. Methods: NEC was induced in male newborn Sprague–Dawley rats by formula feeding, exposure to asphyxia and cold stress. Sixty-four rat pups were divided randomly into four groups: C + NS (n = 11), C + ...
WHOLE BODY - METABOLIC SYNDROME

Colonic Hydrogen Generated from Fructan Diffuses into the Abdominal Cavity and Reduces Adipose mRNA ...

Year Published: 2013

Hydrogen (H2) protects against inflammation-induced oxidative stress. Nondigestible saccharides (NDSs) enhance colonic H2 production. We examined whether colonic H2 transfers to tissues in the abdominal cavity and whether it affects expression of proinflammatory cytokines. In Expts. 1 and 2, rats were fed diets containing fructooligosaccharides [FOSs; 25 (Expt. 1) and 50 g/kg (Expts. 1 and 2)] for ...
HEART - SURGERY/TRANSPLANTATION

A novel method of preserving cardiac grafts using a hydrogen-rich water bath

Year Published: 2013

Background: Exogenously administered hydrogen exerts cytoprotective effects through anti-oxidant, anti-inflammatory, and anti-apoptotic mechanisms in various disease settings, including organ transplantation. Our objective in this study was to evaluate the efficacy of a novel cold storage device equipped with a hydrogen-rich water bath. Methods: The study used an established rat heterotopic ...
BRAIN - STROKE

Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ...

Year Published: 2013

Most of the results regarding hydrogen (H2) therapy for acute cerebral ischemia are derived from in vitro studies and animal experiments, with only a few obtained from human trials with a limited number of subjects. Thus, there is a paucity of information regarding both the beneficial therapeutic effects as well as the side effects of H2 on acute cerebral ischemia in humans. We designed a pilot ...
LUNG - ENVIRONMENTAL POLLUTION

Attenuation of Cigarette Smoke-Induced Airway Mucus Production by Hydrogen-Rich Saline in Rats

Year Published: 2013

Over-production of mucus is an important pathophysiological feature in chronic airway disease such as chronic obstructive pulmonary disease (COPD) and asthma. Cigarette smoking (CS) is the leading cause of COPD. Oxidative stress plays a key role in CS-induced airway abnormal mucus production. Hydrogen protected cells and tissues against oxidative damage by scavenging hydroxyl radicals. In the ...
BLADDER - PAINFUL BLADDER SYNDROME

Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful ...

Year Published: 2013

To investigate the efficacy of hydrogen-rich water for the treatment of patients with interstitial cystitis/painful bladder syndrome (IC/PBS). We conducted a prospective, randomized, double-blind, placebo-controlled clinical trial of hydrogen-rich water in patients with IC/PBS. Inclusion criteria were stable symptoms of IC/PBS for ≥12 weeks after bladder hydrodistension, Interstitial Cystitis ...
SKIN - CANCER

Hydrogen Protects Mice From Dermatitis Caused by Local Radiation

Year Published: 2013

Abstract Background: Radiation therapy produced unwanted side effect on normal tissues, such as radiodermatitis. Hydrogen was previously shown capable of radiation protective in both animals and cell cultures. The effect of hydrogen was now to be investigated on radiation-induced cutaneous. Objective: Development of dermatitis is a frequent side effect of radiotherapy of patients with ...
BRAIN - BRAIN INJURY

The effect of hydrogen gas on a mouse bilateral common carotid artery occlusion

Year Published: 2013

In recent studies, molecular hydrogen selectively reduced the levels of hydroxyl radicals in vitro and exerted a therapeutic anti-oxidant activity in a rat middle cerebral artery occlusion model. The aim of this study was to investigate the effect of hydrogen gas on a mouse bilateral common carotid artery occlusion (BCCAO) model. Male C57BL/6J mice were subjected to transient BCCAO with a ...
BRAIN - STROKE

Hydrogen Inhalation Ameliorated Mast Cell–Mediated Brain Injury After Intracerebral Hemorrhage in ...

Year Published: 2013

Objective: Hydrogen inhalation was neuroprotective in several brain injury models. Its mechanisms are believed to be related to antioxidative stress. We investigated the potential neurovascular protective effect of hydrogen inhalation especially effect on mast cell activation in a mouse model of intracerebral hemorrhage. Design: Controlled in vivo laboratory study. Setting: Animal research ...
BRAIN - PARKINSON'S DISEASE

Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice

Year Published: 2013

The therapeutic potential of molecular hydrogen (H₂) is emerging in a number of human diseases and in their animal models, including in particular Parkinson's disease (PD). H₂ supplementation of drinking water has been shown to exert disease-modifying effects in PD patients and neuroprotective effects in experimental PD model mice. However, H₂ supplementation does not result in detectable ...
SKIN - WOUND HEALING

Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive ...

Year Published: 2013

Background: Pressure ulcer (PU) is common in immobile elderly patients, and there are some research works to investigate a preventive and curative method, but not to find sufficient effectiveness. The aim of this study is to clarify the clinical effectiveness on wound healing in patients with PU by hydrogen-dissolved water (HW) intake via tube-feeding (TF). Furthermore, normal human dermal ...
EYE - DIABETES

Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal ...

Year Published: 2013

Aim: To explore the potential mechanism of molecular hydrogen in the regulation of miRNA expression and signal-modulating activities. Methods: Retinal microglia cells were activated by Lipopolysaccharides (LPS) and then treated with hydrogen-saturated medium or normal medium without hydrogen. qRT-PCR was used to detect the expression difference in miR-9, miR-21 and miR-199 between these two ...
LUNG - SEPSIS

Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury

Year Published: 2013

To study the effects of combined early fluid resuscitation and hydrogen inhalation on septic shock-induced lung and intestine injuries. Wistar male rats were randomly divided into four groups: control group (Group A, n = 15); septic shock group (Group B, n = 15); early fluid resuscitation-treated septic shock group (Group C, n = 15); and early fluid resuscitation and inhalation of 2% ...
WHOLE BODY - SEPSIS

Effects of hydrogen-rich saline treatment on polymicrobial sepsis

Year Published: 2013

Background: Hydrogen has been reported to selectively reduce hydroxyl radicals and peroxynitrite anion in many pathologic processes. This study aimed to test the hypothesis that hydrogen-rich saline (HRS) may ameliorate organ dysfunction in a rat model of polymicrobial sepsis. Methods: Sepsis was induced in male Sprague-Dawley rats by cecal ligation and puncture (CLP). Twenty-four rats were ...
MOUTH - GINGIVITIS

Antibacterial Activity of Hydrogen-rich Water Against Oral Bacteria

Year Published: 2013

There are estimated to be about 700 species of bacteria inthe oral cavity. Based on epidemiological investigations,some of these strains have been proposed as the pathogensresponsible for oral diseases such as dental caries, gingivitisand periodontitis. Since electrolyzed hydrogen-rich waterhas been shown to have beneficial effects on human immunity,its use has increased. In our study, the ...
BONE - SURGERY/TRANSPLANTATION

Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with ...

Year Published: 2013

The bone protective effects of the hydrogen molecule (H2) have been demonstrated in several osteoporosis models while the underlying molecular mechanism has remained unclear. Osteoclast differentiation is an important factor related to the pathogenesis of bone-loss related diseases. In this work, we evaluated the effects of incubation with H2 on receptor activator of NFκB ligand (RANKL)-induced ...