search - Hydrogen Studies

Hydrogen-rich water affected blood alkalinity in physically active men

Year Published: 2014

Possible appliance of effective and safe alkalizing agent in the treatment of metabolic acidosis could be of particular interest to humans experiencing an increase in plasma acidity, such as exercise-induced acidosis. In the present study we tested the hypothesis that the daily oral intake of 2L of hydrogen-rich water (HRW) for 14 days would increase arterial blood alkalinity at baseline and ...

TENDON - EXCERCISE

Effectiveness Of Molecular Hydrogen In The Management Of Musculotendinous Injuries

Year Published: 2014

Muscle and tendon strains (MTS) are often accompanied by subsequent tissue hypoxia and overproduction of reactive oxygen species; this may aggravate the initial cellular damage caused by the actual mechanism of injury. Molecular hydrogen (H2) seems to be beneficial for treating ischemia-reperfusion injury, oxidative stress, and inflammation in human diseases; however, the effects of H2 as an ...

TENDON - EXCERCISE

Effectiveness of Oral and Topical Hydrogen for Sports-Related Soft Tissue Injuries

Year Published: 2014

Background: Because hydrogen therapy has been found beneficial for the treatment of inflammation, ischemia-reperfusion injury, and oxidative stress in humans, it seems useful to evaluate the effects of exogenously administered hydrogen as an element in the immediate management of sports-related soft tissue injuries. The main aim of this pilot study was to examine the effects of 2-week ...

LIVER - ROS-SCAVENGING

Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated ...

Year Published: 2014

The effects of the administration of molecular hydrogen-saturated drinking water (hydrogen water) on hepatic gene expression were investigated in rats. Using DNA microarrays, 548 upregulated and 695 downregulated genes were detected in the liver after 4 weeks of administration of hydrogen water. Gene Ontology analysis revealed that genes for oxidoreduction-related proteins, including ...

LUNG - SURGERY/TRANSPLANTATION

Hydrogen Preconditioning During Ex Vivo Lung Perfusion Improves the Quality of Lung Grafts in Rats

Year Published: 2014

Background: Although the benefits of ex vivo lung perfusion (EVLP) have been globally advocated, the potentially deleterious effects of applying EVLP, in particular activation of proinflammatory cascades and alteration of metabolic profiles, are rarely discussed. This study examined proinflammatory events and metabolic profiles in lung grafts on EVLP and tested whether preconditioning lung grafts ...

PREGNANCY - NEUROPROTECTION

Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in ...

Year Published: 2014

Molecular hydrogen (H2) scavenges hydroxyl radicals. Recently, H2 has been reported to prevent a variety of diseases associated with oxidative stress in model systems and in humans. Here, we studied the effects of H2 on rat fetal hippocampal damage caused by ischemia and reperfusion (IR) on day 16 of pregnancy with the transient occlusion of the bilateral utero-ovarian arteries. Starting 2 days ...

LIVER - SURGERY/TRANSPLANTATION

Beneficial Effects of Hydrogen Gas on Porcine Liver Reperfusion Injury With Use of Total Vascular ...

Year Published: 2014

Background Liver ischemia/reperfusion (I/R) injury is a high risk factor in liver transplantation and it influences graft survival. One of the major events during I/R injury is the generation of cytotoxic oxygen radicals. Recently, hydrogen gas has been reported to have antioxidant properties and protective effects against organ dysfunction induced by I/R injury. The aim of this study is to ...

LIVER - SURGERY/TRANSPLANTATION

Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing ...

Year Published: 2014

The nuclear protein high-mobility group box 1 (HMGB1) is a key trigger for the inflammatory reaction during liver ischemia reperfusion injury (IRI). Hydrogen treatment was recently associated with down-regulation of the expression of HMGB1 and pro-inflammatory cytokines during sepsis and myocardial IRI, but it is not known whether hydrogen has an effect on HMGB1 in liver IRI. Hydrogen enriched ...

BRAIN - TRAUMATIC BRAIN INJURY

Attenuation of diffuse axonal injury by intraperitoneal injection of hydrogen via reducing oxidative ...

Year Published: 2014

To investigate the role of oxidative stress in diffuse axonal injury (DAI) and the therapeutic action of hydrogen in DAI models. Methods Totally 118 adult male SD rats were divided into 3 groups with 39 in each: sham, DAI, and DAI + hydrogen treatment. Rat diffuse axonal injury was induced by an experimental facility, which was developed to make the rat head spin 90 degrees at the moment to cause ...

BRAIN - SEPSIS

Protective effects of inhaled hydrogen gas on cognitive function in mice with sepsis-associated ...

Year Published: 2014

To evaluate protective effects of inhaled hydrogen gas (H2) on cognitive function in a murine model of sepsis-associated encephalopathy (SAE). A total of 84 male ICR mice, weighing 20-25 g, aged 6-8 weeks, were randomly divided into 4 groups of sham, sham+H2, sepsis and sepsis+H2. Sepsis was established by cecal ligation and puncture (CLP). Mice in sham+H2 and sepsis+H2 groups received 2% H2 ...

BRAIN - SEPSIS

Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via ...

Year Published: 2014

During the development of sepsis, the complication in central nervous system (CNS), appearing early and frequently relative to other systems, can obviously increase the mortality of sepsis. Moreover, sepsis survivors also accompany long-term cognitive dysfunction, while the ultimate causes and effective therapeutic strategies of brain injury in sepsis are still not fully clear. We designed this ...

KIDNEY - SEPSIS

A novel fluid resuscitation protocol: Provide more protection on acute kidney injury during septic ...

Year Published: 2014

Objective: To investigate the therapeutic effects of a novel fluid resuscitation protocol (early fluid resuscitation plus 2% hydrogen inhalation) on acute kidney injury during septic shock induced by lipopolysaccharide in rats. Methods: Sixty male Wistar rats were randomly divided into four groups (n = 15 per group): control group (C), septic shock group (S), septic shock with early fluid ...

LIVER - LIVER DISEASE

Effects of hydrogen-rich saline on liver of severely scalded rats with delayed resuscitation

Year Published: 2014

To explore the effects of hydrogen-rich saline (HS) on liver of severely scalded rats with delayed resuscitation. Twenty-four SD rats were inflicted with 40% TBSA full-thickness scald using a temperature-controlled scalding apparatus. The injured rats were divided into lactated Ringer's solution (RS) and HS groups according to the random number table, with 12 rats in each group. Rats in groups RS ...

SPINE - SPINAL CORD INJURY

Molecular hydrogen suppresses reactive astrogliosis related to oxidative injury during spinal cord ...

Year Published: 2014

Aims: Spinal cord injury (SCI) can induce excessive astrocyte activation. Hydrogen has been deemed as a novel antioxidant. We investigated whether molecular hydrogen could act as an antiastrogliosis agent during SCI and oxidative injury in experimental rats and cultured astrocytes. Methods: Hydrogen-rich saline (HS, 8 mL/kg, i.p.) was injected every 12 h after SCI in rats. The expression of STAT3, ...

TESTES - ENVIRONMENTAL POLLUTION

Long-term treatment of hydrogen-rich saline abates testicular oxidative stress induced by nicotine ...

Year Published: 2014

The present study was designed to test the hypothesis that long-term treatment with hydrogen-rich saline abated testicular oxidative stress induced by nicotine in mice. The effects of hydrogen-rich saline (6 ml/kg, i.p.), vitamin C (60 mg/kg, i.p.) and vitamin E (100 mg/kg, i.p.) on reproductive system and testicular oxidative levels in nicotine-treated (4.5 mg/kg, s.b.) mice were investigated. It ...

SKIN - CANCER

Hydration During Breast Radiotherapy May Lower Skin Toxicity

Year Published: 2014

No abstract available

EAR - HEARING LOSS

Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive ...

Year Published: 2014

Reactive oxygen species (ROS) that form in the inner ear play an important role in noise-induced hearing loss (NIHL). Recent studies have revealed that molecular hydrogen (H2) has great potential for reducing ROS. In this study, we examined the potential of hydrogen gas to protect against NIHL. We tested this hypothesis in guinea pigs with 0.5%, 1.0% and 1.5% H2 inhalation in air for 5h a day ...

LIVER - LIVER DISEASE

Concomitant inhibition of oxidative stress and angiogenesis by chronic hydrogen‐rich saline and ...

Year Published: 2014

AimIn cirrhosis, increased oxidative stress leads to systemic and splanchnic hyperdynamic circulation, splanchnic angiogenesis, portosystemic collaterals formation, hepatic endothelial dysfunction, increased intrahepatic resistance, and the subsequent portal hypertension. Like N-acetylcysteine, hydrogen-rich saline is a new documented antioxidant with the potential to treat the complications of ...

LIVER - LIVER DISEASE

Effects of oral intake of hydrogen water on liver fibrogenesis in mice

Year Published: 2014

Aim: Liver fibrosis is the universal consequence of chronic liver diseases. Sustained hepatocyte injury initiates an inflammatory response, thereby activating hepatic stellate cells, the principal fibrogenic cells in the liver. Reactive oxygen species are involved in liver injury and are a promising target for treating liver fibrosis. Hydrogen water is reported to have potential as a therapeutic ...

BRAIN - NEUROPATHIC PAIN

Molecular hydrogen attenuates neuropathic pain in mice

Year Published: 2014

Neuropathic pain remains intractable and the development of new therapeutic strategies are urgently required. Accumulating evidence indicates that overproduction of oxidative stress is a key event in the pathogenesis of neuropathic pain. However, repeated intra-peritoneal or intrathecal injections of antioxidants are unsuitable for continuous use in therapy. Here we show a novel therapeutic method ...

EAR - CANCER

Hydrogen protects auditory hair cells from cisplatin-induced free radicals

Year Published: 2014

Cisplatin is a widely used chemotherapeutic agent for the treatment of various malignancies. However, its maximum dose is often limited by severe ototoxicity. Cisplatin ototoxicity may require the production of reactive oxygen species (ROS) in the inner ear by activating enzymes specific to the cochlea. Molecular hydrogen was recently established as an antioxidant that selectively reduces ROS, and ...

BRAIN - AGING

Electrochemically reduced water protects neural cells from oxidative damage

Year Published: 2014

Aging-related neurodegenerative disorders are closely associated with mitochondrial dysfunction and oxidative stresses and their incidence tends to increase with aging. Brain is the most vulnerable to reactive species generated by a higher rate of oxygen consumption and glucose utilization compared to other organs. Electrochemically reduced water (ERW) was demonstrated to scavenge reactive oxygen ...

HEART - SLEEP APNEA

Hydrogen gas attenuates embryonic gene expression and prevents left ventricular remodeling induced ...

Year Published: 2014

The prevalence of sleep apnea is much higher in patients with heart failure, and intermittent hypoxia (IH) relevant to sleep apnea might induce left ventricular (LV) remodeling. The aim of this study was to investigate the effect of repetitive hypoxic stress on failing heart and to evaluate the antioxidant effect of hydrogen gas. Male Syrian normal (n=22) and cardiomyopathic (CM) (n=33) hamsters ...

BONE - RHEUMATOID ARTHRITIS

Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, ...

Year Published: 2014

The aim of this study was to demonstrate the safety and efficacy of H2-saline infusion for treatment of rheumatoid arthritis (RA). We conducted a randomized, double-blind, placebo-controlled investigation of the infusion of 1 ppm H2-dissolved saline (H2-saline) in 24 RA patients. Patients were randomized 1:1 to receive 500 ml of either H2-saline or placebo-saline, which was drop infused ...

NOSE - RHINOSINUSITIS

Electrolyzed acid water nasal irrigation after functional endoscopic sinus surgery

Year Published: 2014

Electrolyzed acid water (EAW) has been recognized to have strong bactericidal activity, and the feasibility and safety of EAW irrigation in body cavities has been reported in the literature. This study was conducted to evaluate the effect of EAW nasal irrigation on the postoperative care of functional endoscopic sinus surgery (FESS). Patients with chronic rhinosinusitis who received FESS for ...