Search

Studies Found: 1335

SKIN - WOUND HEALING

Effects of Strong Acidic Electrolyzed Water in Wound Healing via Inflammatory and Oxidative Stress ...

Year Published: 2020

Strong acidic electrolyzed water (StAEW) is known to inactivate microorganisms but is not fully explored in the medical field. This study is aimed at exploring StAEW as a potential wound care agent and its mechanism. StAEW (pH: 2.65, ORP: 1159 mV, ACC: 32.1 ppm) was sprayed three times a day to the cutaneous wounds of hairless mice for seven days. Wound morphological and histological features and ...
SKIN - VITILIGO

Molecular Hydrogen Protects Human Melanocytes from Oxidative Stress by Activating Nrf2 Signaling

Year Published: 2020

Oxidative stress is proven to be critical for the initiation and progression of vitiligo. Molecular hydrogen (H2) possesses potent antioxidant activity and has been shown to protect against various oxidative stress-related diseases. In this study, we first investigated the effects and mechanisms of H2 in human melanocytes damaged by hydrogen peroxide. We initially found that H2 reduced ...
BRAIN - STROKE

Hydrogen-rich saline ameliorates hippocampal neuron apoptosis through up-regulating the expression ...

Year Published: 2020

Objectives: This study aimed to evaluate the potential role of hydrogen in rats after cerebral ischemic/reperfusion (I/R) injury. Materials and methods: The experimental samples were composed of sham group, model group of rats that received middle cerebral artery occlusion (MCAO) for 2 hr followed by reperfusion for 24 hr, and the hydrogen saline group treated by hydro¬gen-rich saline (1 ml/kg) ...
LUNG - SARS/COVID

Patient-Reported Health Outcomes After Treatment of COVID-19 with Nebulized and/or Intravenous ...

Year Published: 2020

Background: Coronavirus disease (COVID-19) is currently the main public health problem worldwide. The administration of neutral electrolyzed saline, a solution that contains reactive species of chlorine and oxygen (ROS), may be an effective therapeutic alternative due to its immunomodulating characteristics, in systemic inflammation control, as well as in immune response improvement, promoting ...
BONE - OSTEOARTHRITIS

Protective Effects of Hydrogen-Rich Water Against Cartilage Damage in a Rat Model of Osteoarthritis ...

Year Published: 2020

BACKGROUND The aim of this study was to investigate the mechanisms underlying the potential effects of hydrogen-rich water (HW) on articular cartilage in a rat osteoarthritis (OA) model. MATERIAL AND METHODS A rat model of OA was established using the modified Hulth method, and rats were forced to exercise for 30 min every day 1 week after surgery for 7 weeks. Mankin's method was used to score the ...
WHOLE BODY - INFLAMMATION

Outcomes Assessment of Sustainable and Innovatively Simple Lifestyle Modification at the Workplace ...

Year Published: 2020

Oxidative stress has been associated with many diseases as well as aging. Electrolyzed-reduced water (ERW) has been suggested to reduce oxidative stress and improve antioxidant potential. This study investigated the effects of drinking ERW on biomarkers of oxidative stress and health-related indices in healthy adults. We conducted a randomized, double-blind, placebo-controlled clinical trial on 65 ...
STOMACH - PROTEIN DIGESTION

Hydrogen molecules can modulate enzymatic activity and structural properties of pepsin in vitro

Year Published: 2020

Hydrogen gas therapy has been recognized as the promising application merit. However, the underlying mechanism on the biological effects remains far from being understood. In this work, pepsin used as a research model, the effects of hydrogen-rich water on the protein activities and structural properties were investigated by enzymatic assay, atomic force microscopy-based peakforce quantitative ...
BONE - OSTEONECROSIS

A study on the protective effect of molecular hydrogen on osteoradionecrosis of the jaw in rats

Year Published: 2020

The aim of this study was to investigate the protective effect of hydrogen in a rat model of osteoradionecrosis of the jaw (ORNJ). The rats and bone marrow-derived mesenchymal stem cells (BMSCs) were pre-treated with hydrogen before receiving irradiation (7Gy per fraction, five fractions in total once a day for rats, 4Gy for BMSCs). Reactive oxygen species (ROS) and cell differentiation were ...
LUNG - CANCER

Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system ...

Year Published: 2020

Following standard treatments, the traditional model for enhancing anti-tumor immunity involves performing immune reconstitution (e.g., adoptive immune cell therapies or immunoenhancing drugs) to prevent recurrence. For patients with advanced non-small cell lung cancer, we report here on two objectives, the immunosenescence for advanced non-small cell lung cancer and hydrogen gas inhalation for ...
STOMACH - CANCER

Effects of alkaline water intake on gastritis and miRNA expression (miR-7, miR-155, miR-135b and ...

Year Published: 2020

It is known that abnormal expression of miRNAs in the gastric cancer (GC) contributes to its carcinogenesis. Therefore, ingestion of commercial (usual) water on a daily basis may be a contributing factor for the occurrence of alterations in the gastric mucosal. In this study, it was evaluated the expression of the miRNAs miR-29c, miR-7, miR-155, and miR-135b in the gastric tissue of patients with ...
EYE - CORNEAL INJURY

Retracted: An Immunohistochemical Study of the Increase in Antioxidant Capacity of Corneal ...

Year Published: 2020

Corneal alkali burns are potentially blinding injuries. Alkali induces oxidative stress in corneas followed by excessive corneal inflammation, neovascularization, and untransparent scar formation. Molecular hydrogen (H2), a potent reactive oxygen species (ROS) scavenger, suppresses oxidative stress and enables corneal healing when applied on the corneal surface. The purpose of this study was to ...
WHOLE BODY - INFLAMMATION

Molecular hydrogen protects against oxidative stress-induced RAW 264.7 macrophage cells through the ...

Year Published: 2020

Background Oxidative stress is involved in the development of many inflammatory, metabolic and aging diseases.Objective In this study we investigated, the protective effects of H2 on RAW 264.7 macrophage cell against LPS-and H2O2-induced oxidative stress by the inhibition of MAPK pathway and also activate the Nrf2 pathway.ResultsOur results showed H2 increased the macrophage cell proliferation and ...
WHOLE BODY - EXCERCISE

Hydrogen-Rich Water Supplementation and Up-Hill Running Performance: Effect of Athlete Performance ...

Year Published: 2020

Purpose: Hydrogen-rich water (HRW) has been shown to have an antifatigue effect. This study assessed up-hill running performance, as well as physiological and perceptual responses after supplementation with 1680 mL HRW between 24 h and 40 min before running, in athletes of heterogeneous running ability. Methods: Sixteen males (mean [SD] age 31.6 [8.6] y, VO2max 57.2 [8.9] mL·kg-1·min-1, body fat ...
BRAIN - NEUROPATHIC PAIN

Abstract: Consumption of hydrogen water prevents the occurrence of neuropathic pain in mice

Year Published: 2015

No abstract available
WHOLE BODY - DIABETES

Effects of hydrogen-rich water prepared by alternating-current-electrolysis on antioxidant activity, ...

Year Published: 2020

Hydrogen-rich water is conventionally prepared by direct current-electrolysis, but has been not or scarcely prepared by alternating current (AC)-electrolysis. The AC preparations from tap water for 20-30 minutes exhibit a dissolved hydrogen concentration of 1.55 mg/L, which was close to the theoretical maximum value of 1.6 mg/L. These preparations also displayed an oxidation-reduction potential of ...
BONE - SURGERY/TRANSPLANTATION

Comparative Assessment of In Vitro and In Vivo Biodegradation of Mg-1Ca Magnesium Alloys for ...

Year Published: 2020

Use of magnesium implants is a new trend in orthopedic research because it has several important properties that recommend it as an excellent resorbable biomaterial for implants. In this study, the corrosion rate and behavior of magnesium alloys during the biodegradation process were determined by in vitro assays, evolution of hydrogen release, and weight loss, and further by in vivo assays ...
EYE - CORNEAL INJURY

Hydrogen promotes the activation of Cu, Zn superoxide dismutase in a rat corneal alkali-burn model

Year Published: 2020

Aim: To investigate the effects of hydrogen (H2) on Cu, Zn superoxide dismutase (SOD1) activation in a rat model of corneal alkali burn. Methods: In each rat, one cornea was subjected to alkali exposure. Physiological saline (saline group) or H2-dissolved saline (H2 group) was instilled continuously on the cornea for 5min before and after alkali exposure. Inflammatory cells, neovascularization, ...
STOMACH - CANCER

Hydrogen inhibits the proliferation and migration of gastric cancer cells by modulating lncRNA ...

Year Published: 2021

Background: Gastric cancer is one of the most prevalent and deadly malignancies without efficient treatment option. This study aimed to investigate the effect of hydrogen gas on the behavior of gastric cancer cells. Methods: Gastric cancer cell lines MGC-803 and BGC-823 were treated with or without H2 /O2 gas mixture (66.7%:33.3% v/v). Proliferation and migration were assessed by MTT and scratch ...
LUNG - CANCER

Hydrogen gas activates coenzyme Q10 to restore exhausted CD8 + T cells, especially PD-1 + Tim3 + ...

Year Published: 2020

As previously reported, hydrogen gas improves the prognosis of patients with cancer by restoring exhausted CD8+ T cells into active CD8+ T cells, possibly by activating mitochondria. As mitochondrial activators exhibit synergistic effects with nivolumab, the current study investigated whether hydrogen gas also affects the clinical outcomes of nivolumab. A total of 42 of 56 patients with lung ...
WHOLE BODY - DIABETES (TYPE II)

The protective effect of hydrogen-rich water on rats with type 2 diabetes mellitus

Year Published: 2021

The hydrogen-rich water (HW) has been reported to possess a beneficial role in patients with diabetes. However, a systemic evaluation with an appropriate animal model is necessary to reveal its mechanisms and efficacy. Herein, the protective effects of drinking HW on lipid and glucose metabolism, oxidative stress, and inflammation in type 2 diabetes mellitus (T2DM) rats were investigated. The ...
LUNG - CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary ...

Year Published: 2021

Background: To investigate whether the administration of hydrogen/oxygen mixture was superior to oxygen in improving symptoms in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: This prospective, randomized, double-blind, controlled clinical trial in 10 centres enrolled patient with AECOPD and a Breathlessness, Cough, and Sputum Scale (BCSS) score of at ...
LIVER - LIVER DISEASE

Hydrogen gas alleviates acute alcohol-induced liver injury by inhibiting JNK activation

Year Published: 2021

Binge alcohol drinking is fast becoming a global health concern, with the liver among the first organ involved and the one afflicted with the greatest degree of injury. Oxidative stress, alterations in hepatic metabolism, immunity and inflammation have all been reported to contribute to the development of alcoholic liver disease (ALD). Hydrogen gas (H2) serves a key role in the modulation of ...
BRAIN - PARKINSON'S DISEASE

Hydrogen-saturated saline mediated neuroprotection through autophagy via PI3K/AKT/mTOR pathway in ...

Year Published: 2021

Some cardiovascular symptoms in the early stage of Parkinson's disease (PD) were related to degeneration of the rostral ventrolateral medulla (RVLM) catecholaminergic neurons. To date, little is known about the effects of hydrogen water on early stage of PD. Here, protective actions of hydrogen-saturated saline (HS) on rotenone-induced PD rats, as well as its underlying mechanisms were ...
BRAIN - SEPSIS

Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation ...

Year Published: 2021

Sepsis-associated encephalopathy (SAE) can cause acute and long-term cognitive impairment and increase the mortality rate in sepsis patients, and we previously reported that 2% hydrogen gas (H2) inhalation has a therapeutic effect on SAE, but the underlying mechanism remains unclear. Dynamic DNA methylation, which catalyzed by DNA methyltransferases (DNMTs), is involved in the formation of ...
LUNG - ASTHMA

Molecular hydrogen alleviates asthma through inhibiting IL-33/ILC2 axis

Year Published: 2021

Background: Asthma is one of the most common noninfectious chronic diseases characterized by type II inflammation. This study aimed to investigate the effects of molecular hydrogen on the pathogenesis of asthma. Methods: OVA sensitized asthma mouse model and house dust mite treated 16HBE cellular model were established and hydrogen/oxygen mixture was used to treat asthmatic mice and 16HBE cells. ...