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Studies Found: 1335

WHOLE BODY - OBESITY

Hydrogen Nano-Bubble Water Suppresses ROS Generation, Adipogenesis, and Interleukin-6 Secretion in ...

Year Published: 2021

Reactive oxygen species (ROS)-induced oxidative stress in adipose tissue is associated with inflammation and the development of obesity-related metabolic disorders. The aim of this study is to investigate the effects of hydrogen nano-bubble water (HW) on ROS generation, adipogenesis, and interleukin-6 (IL-6) secretion in hydrogen peroxide (H2O2) or phorbol 12-myristate 13-acetate (PMA)-stimulated ...
BONE - RHEUMATOID ARTHRITIS

Magnesium-Based Micromotors as Hydrogen Generators for Precise Rheumatoid Arthritis Therapy

Year Published: 2021

Hydrogen therapy is an emerging and highly promising strategy for the treatment of inflammation-related diseases. However, nonpolarity and low solubility of hydrogen under the physiological conditions results in a limited therapeutic effect. Herein, we develop a biocompatible magnesium micromotor coated with hyaluronic acid as a hydrogen generator for precise rheumatoid arthritis management. The ...
LIVER - CANCER

In vivo X-ray triggered catalysis of H2 generation for cancer synergistic gas-radiotherapy

Year Published: 2021

To date, hydrogen (H2) therapy has received widespread attention. However, X-ray triggered sustainable H2-producing materials with controlled release for cancer treatment have not been reported. Herein, an X-ray triggered sustainable in situ H2 producing platform, Au NR-TiO2@ZnS:Cu,Co-A(Au-TiO2@ZnS), composed of Au-amorphous TiO2 nano-dumbbell-shaped heterostructure coated with long afterglow ...
BRAIN - PARKINSON'S DISEASE

Effects of concomitant use of hydrogen water and photobiomodulation on Parkinson disease: A pilot ...

Year Published: 2021

Background: Parkinson disease (PD), the second most common neurodegenerative disease, has no cure or applicable disease-modifying approach, only symptomatic therapy. Oxidative stress and mitochondrial dysfunction play key roles in PD pathophysiology. Animal studies have demonstrated that photobiomodulation (PBM) may enhance mitochondrial function and boost adenosine triphosphate production, thus ...
MUSCLE - SURGERY/TRANSPLANTATION

Protective Effect of Hydrogen Gas on Mice Hind Limb Ischemia-Reperfusion Injury

Year Published: 2021

Background: The aim of this study was to investigate the mechanism of hydrogen gas on hind limb IR injury. Methods: Male C57BL/6 mice were randomly divided into three groups: sham group (Sham), ischemia-reperfusion group (IR), IR plus H2 inhalation group (IR + H2). IR was induced by interrupting hind limb blood flow for 3h, followed by 4h of reperfusion, and H2 was administered by inhalation ...
MOUTH - CANCER

Acid-electrolyzed functional water-induces Interleukin-1α release from Intracellular Storage Sites ...

Year Published: 2021

The aim of this study was to examine the acid-electrolyzed functional water (FW)-mediated cytokine release in an oral squamous cell carcinoma-derived cell line (OSCC) following treatment with FW. FW is generated by the electrolysis of a sodium chloride solution and accelerate the burn wound healing. To elucidate the underlying mechanisms, the cytokine/chemokine secretion profile of HSC3 cells was ...
BRAIN - STROKE

Intravenous Hydrogen Therapy With Intracisternal Magnesium Sulfate Infusion in Severe Aneurysmal ...

Year Published: 2021

Background and purpose: Poor-grade subarachnoid hemorrhage still has a poor prognosis. This randomized controlled clinical trial evaluated intracisternal magnesium sulfate infusion combined with intravenous hydrogen therapy in patients with poor-grade subarachnoid hemorrhage. Methods: Thirty-seven patients with poor-grade subarachnoid hemorrhage were randomized to Mg+H2, Mg, and control groups. Mg ...
WHOLE BODY - CANCER

Combined treatment with dissolved hydrogen molecule and platinum nanocolloid exerts ...

Year Published: 2021

Many studies have shown that redox regulation is an effective therapeutic strategy for different types of cancer. We have previously demonstrated that combined treatment with dissolved hydrogen molecule (H2) and platinum nanocolloid (Pt-nc) has carcinostatic effects and that increased intracellular reactive oxygen species (ROS) levels were closely associated with carcinostatic effects in Ehrlich ...
HEART - ATHEROSCLEROSIS

Effects of hydrogen as adjuvant treatment for unstable angina

Year Published: 2021

Oxidative stress and inflammation are closely related to atherosclerotic cardiovascular disease. It is established that hydrogen has significant protective effects on many diseases as a potential antioxidative and anti-inflammatory agent. The purpose of this study is to evaluate the effect of hydrogen on unstable angina in vitro and in vivo. An atherosclerosis model in vitro was constructed by ...
PERITONIUM - SEPSIS

Peritoneal lavage with hydrogen-rich saline can be an effective and practical procedure for acute ...

Year Published: 2021

Purpose: Acute peritonitis has remained a fatal disease despite of recent advances in care and treatment, including antibiotic and anticoagulant treatments. The cause of death is mostly sepsis-induced multiple organ failure. Oxidative stress can play an important role in this situation, but antioxidant therapy to capture any excessive reactive oxygen species has not yet been fully established. ...
KIDNEY - SURGERY/TRANSPLANTATION

Prevention of Chronic Rejection of Marginal Kidney Graft by Using a Hydrogen Gas-Containing ...

Year Published: 2021

In clinical kidney transplantation, the marginal kidney donors are known to develop chronic allograft rejection more frequently than living kidney donors. In our previous study, we have reported that the hydrogen gas-containing organ preservation solution prevented the development of acute injuries in the kidney of the donor after cardiac death by using preclinical miniature pig model. In the ...
KIDNEY - KIDNEY FAILURE

THE USE OF MOLECULAR HYDROGEN IN CORRECTION OF NO-REFLOW SYNDROME IN THE POLYURIC STAGE OF SUBLIMATE ...

Year Published: 2021

Objective - to find out the possibility of using molecular hydrogen in the correction of no-reflow syndrome in the polyuric stage of acute kidney injury 72 hours after the administration of mercuric chloride in rats on a hyposodium diet. The experiments were performed on 60 male white non-linear sexually mature rats weighing 0.16-0.18 kg to study the effect of water loading with saturation with ...
WHOLE BODY - SEPSIS

Hydrogen Gas Therapy Attenuates Inflammatory Pathway Signaling in Septic Mice

Year Published: 2021

Background: Molecular hydrogen (H2) has been used in clinical cases. However, there are few studies of H2 therapy to treat sepsis, and anti-inflammatory mechanisms of H2 are mostly unknown. We aimed to confirm effects of H2 therapy on sepsis and reveal its therapeutic mechanism via RNA sequencing in multiple organs in septic mice. Methods: Nine-week-old C57BL/6 male mice underwent cecal ligation ...
HEART - SURGERY/TRANSPLANTATION

Hydrogen gas inhalation alleviates myocardial ischemia-reperfusion injury by the inhibition of ...

Year Published: 2021

Aims: Reperfusion therapy is the most common and effective treatment against ischemic heart disease (IHD), but the process inflicts massive ischemia/reperfusion (I/R) injury for which no treatment exists. Notably, reperfusion after ischemia causes ischemia/reperfusion injury (IR injury) and the 'no-reflow' phenomenon seriously affecting the therapeutic effects in clinical practice. The principle ...
HEART - METABOLIC SYNDROME

Drinking Molecular Hydrogen Water Is Beneficial to Cardiovascular Function in Diet-Induced Obesity ...

Year Published: 2021

Molecular hydrogen (MH) reportedly exerts therapeutic effects against inflammatory diseases as a suppressor of free radical chain reactions. Here, the cardiovascular protective effects of the intake of molecular hydrogen water (MHW) were investigated using high-fat diet-induced obesity (DIO) mice. MHW was prepared using supplier sticks and degassed water as control. MHW intake for 2 weeks did not ...
WHOLE BODY - CANCER

Drinking Hydrogen-Rich Water Alleviates Chemotherapy-Induced Neuropathic Pain Through the Regulation ...

Year Published: 2021

Introduction: Chemotherapy-induced neuropathic pain (CINP) is one of the most common complications of chemotherapeutic drugs which limits the dose and duration of potentially life-saving anticancer treatment and compromises the quality of life of patients. Our previous studies have reported that molecular hydrogen (H2) can be used to prevent and treat various diseases. But the underlying mechanism ...
BONE - OSTEOARTHRITIS

Hydrogen (H 2) Alleviates Osteoarthritis by Inhibiting Apoptosis and Inflammation via the JNK ...

Year Published: 2021

Background: Osteoarthritis (OA) is a very common condition and leads to joint pain, disability, and price tag all over the world. Pathogenesis of OA is closely related to numerous inflammatory and apoptosis cytokines. Hydrogen (H2) reportedly exhibits a diversity of effects such as anti-apoptotic, anti-inflammatory, and anti-oxidative properties via the JNK pathway. However, it is unknown whether ...
BRAIN - ADDICTION

Hydrogen enriched saline alleviates morphine tolerance via inhibiting neuroinflammation, GLT-1, GS ...

Year Published: 2021

The development and maintenance of morphine tolerance showed association with neuroinflammation and dysfunction of central glutamatergic system (such as nitration of glutamate transporter). Recent evidence indicated that hydrogen could reduce the levels of neuroinflammation and oxidative stress, but its role in morphine tolerance has not been studied. The rats were intrathecally administered with ...
LIVER - NON-ALCOHOLIC STEATOHEPATITIS

Hydrogen-rich water protects liver injury in nonalcoholic steatohepatitis though HO-1 enhancement ...

Year Published: 2021

Nonalcoholic steatohepatitis (NASH) could progress to hepatic fibrosis when absence of effective control. The purpose of our experiment was to investigate the protective effect of drinking water with high concentration of hydrogen in our study named hydrogen rich water (HRW) on mice with non-alcoholic fatty liver disease to elucidate the mechanism underlying the molecular hydrogen therapeutic ...
LUNG - LUNG INJURY

Hydrogen Attenuates Endotoxin-Induced Lung Injury by Activating Thioredoxin 1 and Decreasing Tissue ...

Year Published: 2021

Endotoxin-induced lung injury is one of the major causes of death induced by endotoxemia, however, few effective therapeutic options exist. Hydrogen inhalation has recently been shown to be an effective treatment for inflammatory lung injury, but the underlying mechanism is unknown. In the current study we aim to investigate how hydrogen attenuates endotoxin-induced lung injury and provide ...
PANCREAS - PANCREATITIS

Pre-inhalation of hydrogen-rich gases protect against caerulein-induced mouse acute pancreatitis ...

Year Published: 2021

Background: Acute pancreatitis (AP) lacks targeted prevention and treatment measures. Some key points in the pathogenesis of AP remain unclear, such as early activation of pancreatic enzymes. Several recent reports have shown the protective effect of hydrogen on several AP animal models, and the mechanism is related to antioxidant activity. Heat shock protein 60 (Hsp60) is known to accompany ...
MOUTH - CANCER

Carcinostatic effects of alkanoyl ascorbate plus platinum nano-colloid and stabilization of the ...

Year Published: 2021

Carcinostatic effects of combined use of ascorbic acid (Asc), 2-O-phospho- or 6-O-palmitoyl ascorbate (Asc2Phos, Asc6Palm) or diverse alkanoyl Asc, and nano-sized platinum-poly(N-vinyl-pyrrolidone) colloid (PVP-Pt; 2-nm diameter) were examined on human esophagus carcinoma-derived cells KYSE70. Cell viability was repressed by 'Asc6Palm + PVP-Pt' mixture more markedly than by Asc6Palm or PVP-Pt ...
WHOLE BODY - STRESS RESILIENCE

Heat-retention effects of hydrogen-rich water bath assessed by thermography for humans

Year Published: 2021

Hydrogen-rich water bath devices are commercially available, but have been scarcely clarified for heat-retention effects. In this study, heat-retention effects of hydrogen-rich water bath were assessed by thermographic clinical trials, which employed twenty-four healthy subjects. The thermograms indicated that, under the same conditions (41 °C, 10-min bathing), hydrogen-rich water bath (hydrogen ...
EYE - DRY EYE

Randomized, crossover clinical efficacy trial in humans and mice on tear secretion promotion and ...

Year Published: 2021

The incidence of dry eye disease is increasing worldwide because of the aging population and increasing use of information technology. Dry eye disease manifests as tear-layer instability and inflammation caused by osmotic hypersensitization in tear fluids; however, to our knowledge, no agent that treats both pathologies simultaneously is available. Molecular hydrogen (H2) is known to be effective ...
KIDNEY - DIABETES

Hydrogen water therapy in histopathological improvement of diabetic nephropathy on ...

Year Published: 2021

Diabetic nephropathy (DN) is a renal microvascular abnormality resulting from chronic complications of diabetes mellitus (DM). The main cause of DN is a chronic condition of hyperglycemia which induces oxidative stress in the microvascular system and causes progressive renal failure. Hydrogen water (HW) shows potential in reducing ROS, and anti-inflammatory. This study aims to develop HW therapy ...