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Studies Found: 1104

HEART - SEPSIS

Protective Effects of Hydrogen on Myocardial Mitochondrial Functions in Septic Mice

Year Published: 2020

Enhancement of mitochondrial physiological function prevents sepsis-induced dysfunction. The present study aimed to elucidate the mechanism by which hydrogen (H2) affects mitochondrial function in a wild-type (WT) and homozygous nuclear factor erythroid 2-related factor 2 (Nrf2) knockout (KO, Nrf2−/−) murine model of sepsis. In myocardial tissues with severe sepsis, H2 gas treatment reduced ...
BRAIN - TRAUMATIC BRAIN INJURY

Hydrogen inhalation inhibits microglia activation and neuroinflammation in a rat model of traumatic ...

Year Published: 2020

Traumatic brain injury (TBI) is a major cause of mortality and disability worldwide. To date, therapies to treat any forms of TBI are still limited. Recent studies have demonstrated the potential neuroprotective effects of molecular hydrogen on TBI. Although it has been demonstrated that hydrogen inhalation (HI) for about 5 hrs immediately after TBI has a beneficial effect on brain injury, the ...
BRAIN - ENVIRONMENTAL POLLUTION

Hydrogen rich water ameliorate Trimethyltin induced spatial learning and memory impairment by ...

Year Published: 2020

Background: As an important member of organic tin compounds, Trimethyltin (TMT) exists widely in industrial and agricultural productions. TMT can induce significant neurodegeneration in the limbic system, particular in hippocampus. However, the molecular mechanisms in TMT-induced learning and memory impairment are not fully clear. Thus, this research was to explore the role of Synaptophysin (SYP) ...
BRAIN - BRAIN INJURY

Hydrogen Inhalation Attenuates Oxidative Stress Related Endothelial Cells Injury After Subarachnoid ...

Year Published: 2020

Background: Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular disease with poor clinical outcome. Nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome serves a key role in inflammatory response, which may lead to endothelial cell injury and blood-brain barrier (BBB) disruption. Hydrogen (H2) is considered a neuroprotective ...
BRAIN - SEPSIS

Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia ...

Year Published: 2020

Sepsis-associated encephalopathy (SAE) is the cognitive impairment resulting from sepsis and is associated with increased morbidity and mortality. Hydrogen has emerged as a promising therapeutic agent to alleviate SAE. The mechanism, however, remains unclear. This research aimed to determine whether hydrogen alleviates SAE by regulating microglia polarization and whether it is mediated by the ...
WHOLE BODY - CANCER

Hydrogen gas improves photothermal therapy of tumor and restrains the relapse of distant dormant ...

Year Published: 2019

Inflammation during photothermal therapy (PTT) of tumor usually results in adverse consequences. Here, a biomembrane camouflaged nanomedicine (mPDAB) containing polydopamine and ammonia borane was designed to enhance PTT efficacy and mitigate inflammation. Polydopamine, a biocompatible photothermal agent, can effectively convert light into heat for PTT. Ammonia borane was linked to the surface of ...
BRAIN - ALZHEIMER'S DISEASE (AD)

Sustained release of bioactive hydrogen by Pd hydride nanoparticles overcomes Alzheimer's disease

Year Published: 2019

Oxidative stress-induced mitochondrial dysfunction plays an important role in the pathogenesis of Alzheimer's disease (AD). Hydrogen molecule, a special antioxidant, can selectively scavenge highly cytotoxic reactive oxygen species such as ·OH, exhibiting a potential to treat AD by reducing oxidative stress. However, there is no effective route to realize the continuous and efficient accumulation ...
LIVER - SURGERY/TRANSPLANTATION

Comparative study on protective effect of hydrogen rich saline and adipose-derived stem cells on ...

Year Published: 2019

Aim: To compare and evaluate the hepatoprotective effect of liver parenchyma injection of ADSCs and portal vein injection of HRS in laparoscopic hepatic ischemia reperfusion combined with hepatectomy injury in miniature pigs. Methods: Eighteen miniature pigs were randomly assigned to IRI group, HRS group and ADSCs group. HRS was injected through the portal vein 10 min before reperfusion, 1 d, 2 d, ...
WHOLE BODY - METABOLIC SYNDROME

L-Arabinose Elicits Gut-Derived Hydrogen Production and Ameliorates Metabolic Syndrome in C57BL/6J ...

Year Published: 2019

Obesity and metabolic syndrome (MS) associated with excess calorie intake has become a great public health concern worldwide. L-arabinose, a naturally occurring plant pentose, has a promising future as a novel food ingredient with benefits in MS; yet the mechanisms remain to be further elucidated. Gut microbiota is recently recognized to play key roles in MS. Molecular hydrogen, an emerging ...
HEART - SLEEP APNEA

Hydrogen and Oxygen Mixture to Improve Cardiac Dysfunction and Myocardial Pathological Changes ...

Year Published: 2019

Obstructive sleep apnea (OSA) can cause intermittent changes in blood oxygen saturation, resulting in the generation of many reactive oxygen species (ROS). To discover new antioxidants and clarify the endoplasmic reticulum (ER) stress involved in cardiac injury in OSA, we established a chronic intermittent hypoxia (CIH) rat model with a fraction of inspired O2 (FiO2) ranging from 21% to 9%, 20 ...
SKIN - CANCER

The healing effect of hydrogen-rich water on acute radiation-induced skin injury in rats

Year Published: 2019

This study aimed to determine the healing effect of hydrogen-rich water (HRW) on radiotherapy-induced skin injury. Rats were irradiated with a 6 MeV electron beam from a Varian linear accelerator. After skin wound formation, rats were individually administrated with distilled water, HRW (1.0 ppm) or HRW (2.0 ppm). We measured the healing time and observed the healing rate of the wounded surface. ...
LIVER - OBSTRUCTIVE JAUNDICE

Molecular hydrogen accelerates the reversal of acute obstructive cholangitis‑induced liver ...

Year Published: 2019

Gap junctions (GJs) and tight junctions (TJs) are essential to maintain the function of hepatocytes. Changes in biliary tract pressure and the effect of lipopolysaccharide (LPS) may lead to acute obstructive cholangitis (AOC) and cause liver injury via GJ and TJ dysfunction. Hydrogen has been confirmed to have a protective role in various organs during pathological conditions and inflammation. The ...
WHOLE BODY - PATHOGENIC BACTERIAL LOAD

In vitro biocompatibility study approaches to evaluate the safety profile of electrolyzed water for ...

Year Published: 2019

Electrolyzed water (EW) is a widely used disinfectant agent with high oxidation–reduction potential (ORP). Although EW has been used in many areas, such as food hygiene, agriculture, and animal husbandry, the studies presented in the literature are not enough to clarify the toxic effects of EW. The aim of this study is, therefore, to produce EWs at different pH, ORP, and chlorine concentrations ...
WHOLE BODY - HYDROGEN BIOLOGY

Hydrogen gas distribution in organs after inhalation: Real-time monitoring of tissue hydrogen ...

Year Published: 2019

Hydrogen has therapeutic and preventive effects against various diseases. Although animal and clinical studies have reported promising results, hydrogen distribution in organs after administration remains unclear. Herein, the sequential changes in hydrogen concentration in tissues over time were monitored using a highly sensitive glass microsensor and continuous inhalation of 3% hydrogen gas. The ...
WHOLE BODY - ROS-SCAVENGING

Polymer Dots Compartmentalized in Liposomes as Photocatalyst for In Situ Hydrogen Therapy

Year Published: 2019

Semiconducting polymer dots (Pdots) have recently attracted considerable attention because of their photocatalytic activity as well as tunable optical band gap. In this contribution, we describe the therapeutic application of Pdots through in situ photocatalytic hydrogen generation. A liposome was employed as a nanoreactor to confine the Pdot photocatalyst, reactants, intermediates, and ...
CERVIX - CANCER

Porphyrin-Palladium Hydride MOF Nanoparticles for Tumor-Targeted Photoacoustic Imaging-Guided ...

Year Published: 2019

Hydrogen molecule as important energy gas recently was discovered to have high value in the treatment of many diseases, while the current constraint is low efficacy of stable hydrogen storage and delivery. By virtue of strong hydrogen-binding and catalytic hydrogenation capacity of Pd, here we develop a nanoscale porphyrin-palladium metal-organic framework (Pd-MOF) with highly dispersive Pd atoms ...
LIVER - NON-ALCOHOLIC STEATOHEPATITIS (NASH)

Abstract: Oral Hydrogen water – reduce hepatic inflammatory cells in mouse

Year Published: 2019

No abstract available
INTESTINE - CANCER

Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve ...

Year Published: 2019

Exhausted cluster of differentiation (CD)8+ T cells lose immunological activity due to mitochondrial dysfunction caused by peroxisome proliferator‑activated receptor γ coactivator 1α (PGC‑1α) inactivation, resulting in a poor prognosis in patients with cancer. As hydrogen gas was recently reported to activate PGC‑1α, the present study investigated whether it restores exhausted CD8+ T ...
SKIN - COSMETIC ISSUES

Effects of hydrogen-rich water bath on visceral fat and skin blotch, with boiling-resistant hydrogen ...

Year Published: 2019

Hydrogen-dissolved water has been shown to improve diverse oxidation stress-related diseases, which drove us to examine effects of hydrogen-rich water on oxidation stress-related skin troubles and lipid-metabolism markers. The purpose of this study is whether the dissolved hydrogen in hydrogen-rich water was kept even after boiling, and whether hydrogen-bath utilization improves cosmetic effects ...
BRAIN - DEMENTIA

Effect of Hydrogen Water Drinking on Dementia Patient through Mechanism of Oxidative Stress and ...

Year Published: 2019

Hydrogen water (HW) which is produced by electrolysis of water has characteristics of extremely low oxidation-reduction potential (ORP) value and high dissolved hydrogen (DH). It has been proved to have various beneficial effects including antioxidant and anti-inflammatory effects; however, HW effect on dementia that is associated with cognitive impairment and memory loss, is poorly documented. In ...
INTESTINE - PARKINSON'S DISEASE

Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in ...

Year Published: 2019

There is growing awareness within the scientific community of the strong connection between the inflammation in the intestine and the pathogenesis of Parkinson's disease (PD). In previous studies we developed a PD animal model exposing pup rats to permethrin (PERM) pesticide. Here, we intended to explore whether in our animal model there were changes in gut permeability, fecal microbiota and ...
WHOLE BODY - EXCERCISE

Hydrogen Rich Water Improved Ventilatory, Perceptual and Lactate Responses to Exercise

Year Published: 2019

The potential anti-fatigue and performance benefits of hydrogen rich water (HRW) have resulted in increased research interest over the past 5 years. The aim of this study was to assess physiological and perceptual responses to an incremental exercise protocol after administration of 600 ml HRW within 30 min before exercise. This randomized, double blinded placebo-controlled cross over study ...
BRAIN - BRAIN INJURY

Hydrogen gas therapy improves survival rate and neurological deficits in subarachnoid hemorrhage ...

Year Published: 2019

The high morbidity, high mortality, and significant shortage of effective therapies for subarachnoid hemorrhage (SAH) have created an urgency to discover novel therapies. Human studies in Asia have established the safety of hydrogen gas in the treatment of hepatic, renal, pulmonary, and cardiac diseases. Mechanistically, hydrogen gas has been shown to affect oxidative stress, inflammation, and ...
WHOLE BODY - FASTING

Hydrogen Water on Survival Rate after Fasting in Drosophila Model

Year Published: 2019

In this study, we use a Drosophila model to examine the effect of drinking hydrogen water on survival rate after fasting. The cells produce free radicals to help to absorb nutritious substances due to metabolism, which is a unique phenomenon for biological organisms. But if over the tension of free radicals can seriously affect the physiological functions, and even lead to death. Recently, ...
BRAIN - CARDIOPULMONARY RESUSCITATION (CPR)

Inhaling Hydrogen Ameliorates Early Postresuscitation EEG Characteristics in an Asphyxial Cardiac ...

Year Published: 2019

Background: Electroencephalography (EEG) is commonly used to assess the neurological prognosis of comatose patients after cardiac arrest (CA). However, the early prognostic accuracy of EEG may be affected by postresuscitation interventions. Recent animal studies found that hydrogen inhalation after CA greatly improved neurological outcomes by selectively neutralizing highly reactive oxidants, but ...