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Studies Found: 1179

BONE MARROW - CANCER

Protective effects of hydrogen gas inhalation on radiation-induced bone marrow damage in cancer ...

Year Published: 2021

Although intensity-modulated radiation therapy (IMRT) has been developed as an alternative to conventional radiotherapy, reducing bone marrow damage is limited. Thus, a novel technology is needed to further mitigate IMRT-induced bone marrow damage. Molecular hydrogen (H2) was recently reported as a preventive and therapeutic antioxidant that selectively scavenges hydroxyl radical (·OH) and ...
MOUTH - PERIODONTITIS

Assessment of antibacterial effect of hydrogen water on plaque from patients with chronic ...

Year Published: 2021

Background: Periodontitis is an inflammatory disease causing destruction of tissues surrounding the teeth. The primary etiological factor for periodontitis is plaque. An inference could be drawn that an overall reduction in microorganisms halts disease progression. It is desirable to have natural agents with minimal side effects to reduce the microbial load. Aim: The aim of the study is to assess ...
WHOLE BODY - STRESS RESILIENCE

Alleviation of the chronic stress response attributed to the antioxidant and anti-inflammatory ...

Year Published: 2021

Reactive oxygen species (ROS) are highly reactive and directly attack surrounding biomolecules to deteriorate cellular and tissue functions. Meanwhile, ROS also serve as signaling mediators to upregulate pro-inflammatory cytokine expression via activation of the nuclear factor kappa B signaling pathway, and the increased pro-inflammatory cytokines trigger respiratory burst of inflammatory cells ...
WHOLE BODY - EXCERCISE

Effects of an H2-infused, Nitric Oxide-Producing Functional Beverage on Exercise and Cognitive ...

Year Published: 2021

Background. Exercise performance and recovery are impaired by excessive levels of oxidative stress and inflammation. However, both reactive oxygen species (ROS) and inflammation improve exercise performance including mitochondrial ATP production and force of muscle contraction. They also are essential mediators in providing the benefits and training adaptations that occur from exercise. Nitric ...
KIDNEY - DIABETES

Hydrogen water therapy in histopathological improvement of diabetic nephropathy on ...

Year Published: 2021

Diabetic nephropathy (DN) is a renal microvascular abnormality resulting from chronic complications of diabetes mellitus (DM). The main cause of DN is a chronic condition of hyperglycemia which induces oxidative stress in the microvascular system and causes progressive renal failure. Hydrogen water (HW) shows potential in reducing ROS, and anti-inflammatory. This study aims to develop HW therapy ...
LUNG - SEPSIS

Hydrogen alleviates cell damage and acute lung injury in sepsis via PINK1/Parkin-mediated mitophagy

Year Published: 2021

Background: Multiple organ failure (MOF) is the main cause of early death in septic shock. Lungs are among the organs that are affected in MOF, resulting in acute lung injury. Inflammation is an important factor that causes immune cell dysfunction in the pathogenesis of sepsis. Autophagy is involved in the process of inflammation and also occurs in response to cell and tissue injury in several ...
MOUTH - CANCER

Carcinostatic effects of alkanoyl ascorbate plus platinum nano-colloid and stabilization of the ...

Year Published: 2021

Carcinostatic effects of combined use of ascorbic acid (Asc), 2-O-phospho- or 6-O-palmitoyl ascorbate (Asc2Phos, Asc6Palm) or diverse alkanoyl Asc, and nano-sized platinum-poly(N-vinyl-pyrrolidone) colloid (PVP-Pt; 2-nm diameter) were examined on human esophagus carcinoma-derived cells KYSE70. Cell viability was repressed by 'Asc6Palm + PVP-Pt' mixture more markedly than by Asc6Palm or PVP-Pt ...
EYE - CORNEAL INJURY

Molecular Hydrogen Attenuated N-methyl-N-Nitrosourea Induced Corneal Endothelial Injury by ...

Year Published: 2021

Purpose: Previous work by our group has demonstrated the value of N-methyl-N-nitrosourea (MNU)-induced corneal endothelial decompensation in animal models. The aim of this study was to investigate the effect of molecular hydrogen (H2) on MNU-induced corneal endothelial cell (CEC) injury and the underlying mechanism. Methods: MNU-induced animal models of CEC injury were washed with hydrogen-rich ...
WHOLE BODY - STRESS RESILIENCE

Heat-retention effects of hydrogen-rich water bath assessed by thermography for humans

Year Published: 2021

Hydrogen-rich water bath devices are commercially available, but have been scarcely clarified for heat-retention effects. In this study, heat-retention effects of hydrogen-rich water bath were assessed by thermographic clinical trials, which employed twenty-four healthy subjects. The thermograms indicated that, under the same conditions (41 °C, 10-min bathing), hydrogen-rich water bath (hydrogen ...
INTESTINE - INDIGESTION

The effects of ingestion of hydrogen-dissolved alkaline electrolyzed water on stool consistency and ...

Year Published: 2021

A relationship between Bifidobacterium and defecation has previously been reported. Our hypothesis on the effectiveness of alkaline electrolyzed water (AEW) proposes that ingestion of AEW, considered possessing antioxidative properties, increases the number of Bifidobacteria and improves stool hardness and gastrointestinal symptoms. A double-blind, randomized study was conducted to evaluate the ...
EYE - DRY EYE

Randomized, crossover clinical efficacy trial in humans and mice on tear secretion promotion and ...

Year Published: 2021

The incidence of dry eye disease is increasing worldwide because of the aging population and increasing use of information technology. Dry eye disease manifests as tear-layer instability and inflammation caused by osmotic hypersensitization in tear fluids; however, to our knowledge, no agent that treats both pathologies simultaneously is available. Molecular hydrogen (H2) is known to be effective ...
BRAIN - BRAIN INJURY

Hydrogen gas post-conditioning attenuates early neuronal pyroptosis in a rat model of subarachnoid ...

Year Published: 2021

Neuronal pyroptosis serves an important role in the progress of neurologic dysfunction following subarachnoid hemorrhage (SAH), which is predominantly caused by a ruptured aneurysm. Hydrogen gas has been previously reported to be an effective anti-inflammatory agent against ischemia-associated diseases by regulating mitochondrial function. The objective of the present study was to investigate the ...
PANCREAS - PANCREATITIS

Pre-inhalation of hydrogen-rich gases protect against caerulein-induced mouse acute pancreatitis ...

Year Published: 2021

Background: Acute pancreatitis (AP) lacks targeted prevention and treatment measures. Some key points in the pathogenesis of AP remain unclear, such as early activation of pancreatic enzymes. Several recent reports have shown the protective effect of hydrogen on several AP animal models, and the mechanism is related to antioxidant activity. Heat shock protein 60 (Hsp60) is known to accompany ...
EAR - HEARING LOSS

Inhalation of Molecular Hydrogen, a Rescue Treatment for Noise-Induced Hearing Loss

Year Published: 2021

Noise exposure is the most important external factor causing acquired hearing loss in humans, and it is strongly associated with the production of reactive oxygen species (ROS) in the cochlea. Several studies reported that the administration of various compounds with antioxidant effects can treat oxidative stress-induced hearing loss. However, traditional systemic drug administration to the human ...
LUNG - LUNG INJURY

Hydrogen Attenuates Endotoxin-Induced Lung Injury by Activating Thioredoxin 1 and Decreasing Tissue ...

Year Published: 2021

Endotoxin-induced lung injury is one of the major causes of death induced by endotoxemia, however, few effective therapeutic options exist. Hydrogen inhalation has recently been shown to be an effective treatment for inflammatory lung injury, but the underlying mechanism is unknown. In the current study we aim to investigate how hydrogen attenuates endotoxin-induced lung injury and provide ...
BRAIN - ADDICTION

Hydrogen enriched saline alleviates morphine tolerance via inhibiting neuroinflammation, GLT-1, GS ...

Year Published: 2021

The development and maintenance of morphine tolerance showed association with neuroinflammation and dysfunction of central glutamatergic system (such as nitration of glutamate transporter). Recent evidence indicated that hydrogen could reduce the levels of neuroinflammation and oxidative stress, but its role in morphine tolerance has not been studied. The rats were intrathecally administered with ...
LIVER - NON-ALCOHOLIC STEATOHEPATITIS (NASH)

Hydrogen-rich water protects liver injury in nonalcoholic steatohepatitis though HO-1 enhancement ...

Year Published: 2021

Nonalcoholic steatohepatitis (NASH) could progress to hepatic fibrosis when absence of effective control. The purpose of our experiment was to investigate the protective effect of drinking water with high concentration of hydrogen in our study named hydrogen rich water (HRW) on mice with non-alcoholic fatty liver disease to elucidate the mechanism underlying the molecular hydrogen therapeutic ...
WHOLE BODY - CANCER

Drinking Hydrogen-Rich Water Alleviates Chemotherapy-Induced Neuropathic Pain Through the Regulation ...

Year Published: 2021

Introduction: Chemotherapy-induced neuropathic pain (CINP) is one of the most common complications of chemotherapeutic drugs which limits the dose and duration of potentially life-saving anticancer treatment and compromises the quality of life of patients. Our previous studies have reported that molecular hydrogen (H2) can be used to prevent and treat various diseases. But the underlying mechanism ...
BONE - OSTEOARTHRITIS (OA)

Hydrogen (H 2) Alleviates Osteoarthritis by Inhibiting Apoptosis and Inflammation via the JNK ...

Year Published: 2021

Background: Osteoarthritis (OA) is a very common condition and leads to joint pain, disability, and price tag all over the world. Pathogenesis of OA is closely related to numerous inflammatory and apoptosis cytokines. Hydrogen (H2) reportedly exhibits a diversity of effects such as anti-apoptotic, anti-inflammatory, and anti-oxidative properties via the JNK pathway. However, it is unknown whether ...
HEART - METABOLIC SYNDROME

Drinking Molecular Hydrogen Water Is Beneficial to Cardiovascular Function in Diet-Induced Obesity ...

Year Published: 2021

Molecular hydrogen (MH) reportedly exerts therapeutic effects against inflammatory diseases as a suppressor of free radical chain reactions. Here, the cardiovascular protective effects of the intake of molecular hydrogen water (MHW) were investigated using high-fat diet-induced obesity (DIO) mice. MHW was prepared using supplier sticks and degassed water as control. MHW intake for 2 weeks did not ...
WHOLE BODY - SEPSIS

Hydrogen Gas Therapy Attenuates Inflammatory Pathway Signaling in Septic Mice

Year Published: 2021

Background: Molecular hydrogen (H2) has been used in clinical cases. However, there are few studies of H2 therapy to treat sepsis, and anti-inflammatory mechanisms of H2 are mostly unknown. We aimed to confirm effects of H2 therapy on sepsis and reveal its therapeutic mechanism via RNA sequencing in multiple organs in septic mice. Methods: Nine-week-old C57BL/6 male mice underwent cecal ligation ...
HEART - SURGERY/TRANSPLANTATION

Hydrogen gas inhalation alleviates myocardial ischemia-reperfusion injury by the inhibition of ...

Year Published: 2021

Aims: Reperfusion therapy is the most common and effective treatment against ischemic heart disease (IHD), but the process inflicts massive ischemia/reperfusion (I/R) injury for which no treatment exists. Notably, reperfusion after ischemia causes ischemia/reperfusion injury (IR injury) and the 'no-reflow' phenomenon seriously affecting the therapeutic effects in clinical practice. The principle ...
KIDNEY - SURGERY/TRANSPLANTATION

Prevention of Chronic Rejection of Marginal Kidney Graft by Using a Hydrogen Gas-Containing ...

Year Published: 2021

In clinical kidney transplantation, the marginal kidney donors are known to develop chronic allograft rejection more frequently than living kidney donors. In our previous study, we have reported that the hydrogen gas-containing organ preservation solution prevented the development of acute injuries in the kidney of the donor after cardiac death by using preclinical miniature pig model. In the ...
KIDNEY - CHRONIC KIDNEY DISEASE

Hydrogen-rich water reduced oxidative stress and renal fibrosis in rats with unilateral ureteral ...

Year Published: 2021

Background: Congenital obstructive nephropathy (CKD) is commonly implicated in the pathophysiology of chronic kidney disease occurring in the pediatric and adolescent age groups and the release of reactive oxygen species contribute to the worsening of renal fibrosis. Molecular hydrogen (H2) protects against tissue injury by reducing oxidative stress. We evaluated the efficacy of oral H2-rich water ...
KIDNEY - KIDNEY FAILURE

THE USE OF MOLECULAR HYDROGEN IN CORRECTION OF NO-REFLOW SYNDROME IN THE POLYURIC STAGE OF SUBLIMATE ...

Year Published: 2021

Objective - to find out the possibility of using molecular hydrogen in the correction of no-reflow syndrome in the polyuric stage of acute kidney injury 72 hours after the administration of mercuric chloride in rats on a hyposodium diet. The experiments were performed on 60 male white non-linear sexually mature rats weighing 0.16-0.18 kg to study the effect of water loading with saturation with ...