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Studies Found: 1093

SKIN - CANCER

The healing effect of hydrogen-rich water on acute radiation-induced skin injury in rats

Year Published: 2019

This study aimed to determine the healing effect of hydrogen-rich water (HRW) on radiotherapy-induced skin injury. Rats were irradiated with a 6 MeV electron beam from a Varian linear accelerator. After skin wound formation, rats were individually administrated with distilled water, HRW (1.0 ppm) or HRW (2.0 ppm). We measured the healing time and observed the healing rate of the wounded surface. ...
LIVER - SEPSIS

Molecular hydrogen accelerates the reversal of acute obstructive cholangitis‑induced liver ...

Year Published: 2019

Gap junctions (GJs) and tight junctions (TJs) are essential to maintain the function of hepatocytes. Changes in biliary tract pressure and the effect of lipopolysaccharide (LPS) may lead to acute obstructive cholangitis (AOC) and cause liver injury via GJ and TJ dysfunction. Hydrogen has been confirmed to have a protective role in various organs during pathological conditions and inflammation. The ...
WHOLE BODY - PATHOGENIC BACTERIAL LOAD

In vitro biocompatibility study approaches to evaluate the safety profile of electrolyzed water for ...

Year Published: 2019

Electrolyzed water (EW) is a widely used disinfectant agent with high oxidation–reduction potential (ORP). Although EW has been used in many areas, such as food hygiene, agriculture, and animal husbandry, the studies presented in the literature are not enough to clarify the toxic effects of EW. The aim of this study is, therefore, to produce EWs at different pH, ORP, and chlorine concentrations ...
WHOLE BODY - HYDROGEN BIOLOGY

Hydrogen gas distribution in organs after inhalation: Real-time monitoring of tissue hydrogen ...

Year Published: 2019

Hydrogen has therapeutic and preventive effects against various diseases. Although animal and clinical studies have reported promising results, hydrogen distribution in organs after administration remains unclear. Herein, the sequential changes in hydrogen concentration in tissues over time were monitored using a highly sensitive glass microsensor and continuous inhalation of 3% hydrogen gas. The ...
WHOLE BODY - ROS-SCAVENGING

Polymer Dots Compartmentalized in Liposomes as Photocatalyst for In Situ Hydrogen Therapy

Year Published: 2019

Semiconducting polymer dots (Pdots) have recently attracted considerable attention because of their photocatalytic activity as well as tunable optical band gap. In this contribution, we describe the therapeutic application of Pdots through in situ photocatalytic hydrogen generation. A liposome was employed as a nanoreactor to confine the Pdot photocatalyst, reactants, intermediates, and ...
CERVIX - CANCER

Porphyrin-Palladium Hydride MOF Nanoparticles for Tumor-Targeted Photoacoustic Imaging-Guided ...

Year Published: 2019

Hydrogen molecule as important energy gas recently was discovered to have high value in the treatment of many diseases, while the current constraint is low efficacy of stable hydrogen storage and delivery. By virtue of strong hydrogen-binding and catalytic hydrogenation capacity of Pd, here we develop a nanoscale porphyrin-palladium metal-organic framework (Pd-MOF) with highly dispersive Pd atoms ...
LIVER - STEATOHEPATITIS, NON-ALCOHOLIC (NASH)

Abstract: Oral Hydrogen water – reduce hepatic inflammatory cells in mouse

Year Published: 2019

No abstract available
INTESTINE - CANCER

Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve ...

Year Published: 2019

Exhausted cluster of differentiation (CD)8+ T cells lose immunological activity due to mitochondrial dysfunction caused by peroxisome proliferator‑activated receptor γ coactivator 1α (PGC‑1α) inactivation, resulting in a poor prognosis in patients with cancer. As hydrogen gas was recently reported to activate PGC‑1α, the present study investigated whether it restores exhausted CD8+ T ...
SKIN - COSMETIC ISSUES

Effects of hydrogen-rich water bath on visceral fat and skin blotch, with boiling-resistant hydrogen ...

Year Published: 2019

Hydrogen-dissolved water has been shown to improve diverse oxidation stress-related diseases, which drove us to examine effects of hydrogen-rich water on oxidation stress-related skin troubles and lipid-metabolism markers. The purpose of this study is whether the dissolved hydrogen in hydrogen-rich water was kept even after boiling, and whether hydrogen-bath utilization improves cosmetic effects ...
BRAIN - DEMENTIA

Effect of Hydrogen Water Drinking on Dementia Patient through Mechanism of Oxidative Stress and ...

Year Published: 2019

Hydrogen water (HW) which is produced by electrolysis of water has characteristics of extremely low oxidation-reduction potential (ORP) value and high dissolved hydrogen (DH). It has been proved to have various beneficial effects including antioxidant and anti-inflammatory effects; however, HW effect on dementia that is associated with cognitive impairment and memory loss, is poorly documented. In ...
INTESTINE - PARKINSON'S DISEASE

Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in ...

Year Published: 2019

There is growing awareness within the scientific community of the strong connection between the inflammation in the intestine and the pathogenesis of Parkinson's disease (PD). In previous studies we developed a PD animal model exposing pup rats to permethrin (PERM) pesticide. Here, we intended to explore whether in our animal model there were changes in gut permeability, fecal microbiota and ...
WHOLE BODY - EXCERCISE

Hydrogen Rich Water Improved Ventilatory, Perceptual and Lactate Responses to Exercise

Year Published: 2019

The potential anti-fatigue and performance benefits of hydrogen rich water (HRW) have resulted in increased research interest over the past 5 years. The aim of this study was to assess physiological and perceptual responses to an incremental exercise protocol after administration of 600 ml HRW within 30 min before exercise. This randomized, double blinded placebo-controlled cross over study ...
BRAIN - BRAIN INJURY

Hydrogen gas therapy improves survival rate and neurological deficits in subarachnoid hemorrhage ...

Year Published: 2019

The high morbidity, high mortality, and significant shortage of effective therapies for subarachnoid hemorrhage (SAH) have created an urgency to discover novel therapies. Human studies in Asia have established the safety of hydrogen gas in the treatment of hepatic, renal, pulmonary, and cardiac diseases. Mechanistically, hydrogen gas has been shown to affect oxidative stress, inflammation, and ...
WHOLE BODY - FASTING

Hydrogen Water on Survival Rate after Fasting in Drosophila Model

Year Published: 2019

In this study, we use a Drosophila model to examine the effect of drinking hydrogen water on survival rate after fasting. The cells produce free radicals to help to absorb nutritious substances due to metabolism, which is a unique phenomenon for biological organisms. But if over the tension of free radicals can seriously affect the physiological functions, and even lead to death. Recently, ...
BRAIN - CARDIOPULMONARY RESUSCITATION (CPR)

Inhaling Hydrogen Ameliorates Early Postresuscitation EEG Characteristics in an Asphyxial Cardiac ...

Year Published: 2019

Background: Electroencephalography (EEG) is commonly used to assess the neurological prognosis of comatose patients after cardiac arrest (CA). However, the early prognostic accuracy of EEG may be affected by postresuscitation interventions. Recent animal studies found that hydrogen inhalation after CA greatly improved neurological outcomes by selectively neutralizing highly reactive oxidants, but ...
BRAIN - NEUROPATHIC PAIN

Hydrogen-rich Saline Alleviated the Hyperpathia and Microglia Activation via Autophagy Mediated ...

Year Published: 2019

Neuropathic pain is a complication after a spinal nerve injury. The inflammasomes are now identified to be responsible for triggering inflammation in neuropathic pain. Autophagy participates in the process of neuropathic pain and can regulate the inflammasome activation in different diseases. Our previous research reported that hydrogen exerted a protective effect against neuropathic pain. ...
WHOLE BODY - SEPSIS

Hydrogen alleviated organ injury and dysfunction in sepsis: The role of cross-talk between autophagy ...

Year Published: 2019

Aims: Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. Although much progress has been made in understanding the pathophysiology of sepsis, further discussion and study of the detailed therapeutic mechanisms are needed. Autophagy and endoplasmic reticulum stress are two pathways of the complicated regulatory network of sepsis. ...
WHOLE BODY - SEPSIS

Hydrogen alleviates mitochondrial dysfunction and organ damage via autophagy‑mediated NLRP3 ...

Year Published: 2019

Sepsis is a highly heterogeneous syndrome that is caused by a dysregulated host response to infection. The disproportionate inflammatory response to invasive infection is a triggering event inducing sepsis. The activation of inflammasomes in sepsis can amplify inflammatory responses. It has been reported that damaged mitochondria contribute to NACHT, LRR and PYD domains‑containing protein 3 ...
BRAIN - CANCER

Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A ...

Year Published: 2019

Lung cancer is the most common type of tumor, prone to contralateral lung, bone and brain metastasis. We report a 44-year-old woman diagnosed with lung cancer with multiple metastases in November 2015. Oral targeted drugs were initiated after the removal of brain metastases, and most lesions remained stable for 28 months. In March 2018, intracranial multiple metastases, as well as hydrocephalus ...
GALLBLADDER - CANCER

A Gallbladder Carcinoma Patient With Pseudo-Progressive Remission After Hydrogen Inhalation

Year Published: 2019

Background: Hydrogen therapy has been reported to convert exhausted programmed cell death receptor (PD-1)+CD8+ T cells to PD-1-CD8+ T cells, in advanced colorectal cancer patients, which is associated with significantly prolonged survival. Case presentation: A 72-year-old female patient presented with metastatic gallbladder cancer and underwent symptomatic treatment combined with hydrogen therapy. ...
GALLBLADDER - CANCER

Hydrogen gas therapy induced shrinkage of metastatic gallbladder cancer: A case report

Year Published: 2019

Background: We present the case of a 72-year-old female patient with gallbladder cancer (GBC) who developed in situ recurrence and liver metastases 9 mo after irreversible electroporation ablation and oral tegafur (a fluoropyrimidine derivative) chemotherapy, which failed to control the progression of the disease. The patient further developed metastases in the lymph nodes around the head of the ...
WHOLE BODY - CANCER

Real world survey' of hydrogen-controlled cancer: A follow-up report of 82 advanced cancer patients

Year Published: 2019

Advanced cancer treatment is a huge challenge and new ideas and strategies are required. Hydrogen exerts antioxidant and anti-inflammatory effects that may be exploited to control cancer, the occurrence and progression of which is closely related to peroxidation and inflammation. We conducted a prospective follow-up study of 82 patients with stage III and IV cancer treated with hydrogen inhalation ...
MOUTH - DENTIN INTEGRITY

Influence of the acidity of electrolyzed water on the microhardness of inner layer dentin

Year Published: 2019

Background/purpose: Electrolyzed water has been identified as an effective disinfectant that could represent as an alternative to sodium hypochlorite. Unfortunately, it remains unclear whether the texture or physical properties of dentin are affected by the application of electrolyzed water of different acidities. This study was aimed to assess the influence of electrolyzed waters with differing ...
BRAIN - STROKE

UPLC-QTOF/MS-Based Metabolomics Reveals the Protective Mechanism of Hydrogen on Mice with Ischemic ...

Year Published: 2019

As a reductive gas, hydrogen plays an antioxidant role by selectively scavenging oxygen free radicals. It has been reported that hydrogen has protective effects against nerve damage caused by ischemia–reperfusion in stroke, but the specific mechanism is still unclear. Therefore, this study aims to investigate the protective effects of hydrogen on stroke-induced ischemia–reperfusion injury and ...
BRAIN - BRAIN INJURY

Hydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to ...

Year Published: 2019

Background Hypoxia-ischemia (HI) during the perinatal period is one of the most common causes of acute mortality and chronic neurologic morbidity. Hydrogen-rich saline (HS) treatment in neonatal mice has been reported to alleviate brain injury following HI, but the mechanisms involved are not known. Methods A modified version of the Rice-Vannucci method for the induction of neonatal HI brain ...