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Studies Found: 1138

LUNG - SURGERY/TRANSPLANTATION

Hydrogen-Rich Saline Attenuates Lung Ischemia-Reperfusion Injury in Rabbits

Year Published: 2012

Hydrogen gas, an antioxidant agent, was found to protect against cerebral and myocardial ischemia-reperfusion (I/R) injury. In the present study, we investigated the effect of hydrogen-rich saline (HRS) on the I/R-induced lung injury. Left lung of male New Zealand White rabbits rendered normothermic ischemia for 60 min and reperfused for up to 240 min. Treated animals received intraperitoneal ...
WHOLE BODY - RADIOPROTECTION

Abstract 12: HYDROGEN: A NOVEL RADIOPROTECTIVE AGENT

Year Published: 2012

No abstract available
BRAIN - STROKE

Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via ...

Year Published: 2012

Hydrogen gas (H(2)) as a new medical gas exerts organ-protective effects through regulating oxidative stress, inflammation and apoptosis. In contrast to H(2), hydrogen-rich saline (HS) may be more suitable for clinical application. The present study was designed to investigate whether HS can offer a neuroprotective effect in a rat model of permanent focal cerebral ischemia and what mechanism(s) ...
LUNG - SEPSIS

Effect of hydrogen inhalation on p38 MAPK activation in rats with lipopolysaccharide- induced acute ...

Year Published: 2012

Objective: To investigate the effect of hydrogen inhalation on lipopolysaccharide (LPS)-induced acute lung injury (ALI) and the underlying molecular mechanisms. Methods: Thirty-two male SD rats were randomly divided into 4 groups (n=8), namely the normal saline group (SA), saline with 2% hydrogen gas inhalation group (SH group), ALI group, and ALI with hydrogen inhalation group (LH group). In the ...
STOMACH - GASTRIC ULCER

The protective of hydrogen on stress-induced gastric ulceration

Year Published: 2012

Stress ulceration frequently occurs as a result of major stressful events and hydroxyl radical (⋅OH) is one of the major causative factors for it. Recently, it has been proved that hydrogen, a potent selectively ⋅OH scavenger, can effectively protect animals against ROS-induced tissue damage. In like manner, we hypothesize that hydrogen may have a protective effect against stress ulceration. ...
BRAIN - BRAIN INJURY

Effect of Hydrogen Gas on the Survival Rate of Mice Following Global Cerebral Ischemia.

Year Published: 2012

Global cerebral ischemia and reperfusion (I/R) often result in high mortality. Free radicals have been reported to play an important role in global cerebral I/R, and therefore, reduction of these might improve the outcome. Here, we investigated the effect of hydrogen gas (H2) (a strong free radical scavenger) on the survival rate of mice following global cerebral I/R. We further examined the ...
HEART - SURGERY/TRANSPLANTATION

Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated ...

Year Published: 2012

Recent evidence suggests that molecular hydrogen has therapeutic value for disease states that involve inflammation. We hypothesized that drinking hydrogen-rich water (HW) daily would protect cardiac and aortic allograft recipients from inflammation-associated deterioration. Heterotopic heart transplantation with short-course tacrolimus immunosuppression and orthotopic aortic transplantation were ...
BRAIN - HYDROGEN BIOLOGY

A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety ...

Year Published: 2012

Background: In animal experiments, use of molecular hydrogen ( H2) has been regarded as quite safe and effective, showing benefits in multiple pathological conditions such as ischemia-reperfusion injury of the brain, heart, kidney and transplanted tissues, traumatic and surgical injury of the brain and spinal cord, inflammation of intestine and lung , degenerative striatonigral tissue and also in ...
SKIN - ERYTHEMA

Hydrogen (H2) treatment for acute erythymatous skin disease. A report of 4 patients with safety data ...

Year Published: 2012

We have treated 4 patients of acute erythematous skin diseases with fever and/or pain by H2 enriched intravenous fluid. We also added data from two volunteers for assessing the mode of H2 delivery to the skin for evaluation of feasibility of H2 treatment for this type of skin diseases. All of the four patients received intravenous administration of 500 ml of H2 enriched fluid in 30 min for ...
BLOOD - BLOOD COMPOSITION

Serum alkalinization and hydrogen-rich water in healthy men

Year Published: 2012

No abstract available
WHOLE BODY - ENVIRONMENTAL POLLUTION

Electrolyzed-reduced water confers increased resistance to environmental stresses

Year Published: 2012

Electrolysis of water produces reduced water at the cathode and oxidized water at the anode. Electrolyzed-reduced water (ERW) has an extremely negative oxidation-reduction potential. ERW scavenges cellular reactive oxygen species (ROS) and suppresses single-strand breaks of plasmid DNA in bacteria. Here, we examined the effect of ERW on resistance to oxidative stress both in vitro and in vivo. ...
HEART - SURGERY/TRANSPLANTATION

Hydrogen-rich saline prevents neointima formation after carotid balloon injury by suppressing ROS ...

Year Published: 2012

Background: Reactive oxygen species (ROS) play a pivotal role in neointima hyperplasia after balloon injury. Molecular hydrogen has emerged as a novel antioxidant and has been proven effective in treating many diseases. Objectives: We aimed to determine the mechanism by which hydrogen affects neointima formation. Methods: We assessed the influence of a hydrogen-rich saline solution (HRSS) by daily ...
EAR - HEARING LOSS

Inhalation of hydrogen gas attenuates ouabain-induced auditory neuropathy in gerbils

Year Published: 2012

Aim: Auditory neuropathy (AN) is a hearing disorder characterized by abnormal auditory nerve function with preservation of normal cochlear hair cells. This study was designed to investigate whether treatment with molecular hydrogen (H(2)), which can remedy damage in various organs via reducing oxidative stress, inflammation and apoptosis, is beneficial to ouabain-induced AN in gerbils. Methods: AN ...
PANCREAS - PANCREATITIS

Hydrogen-rich saline reduces the oxidative stress and relieves the severity of trauma-induced acute ...

Year Published: 2012

Currently, little evidence exists to support whether the therapeutic approaches for treating ordinary acute pancreatitis (AP) are effective in trauma-induced pancreatitis. Hydrogen-rich (H2) saline is an antioxidant treatment capable of ameliorating the severity of L-arginine-induced AP. In this study, we attempted to validate its protective role against traumatic pancreatitis (TP). A previously ...
WHOLE BODY - AGING

Does alkaline-reduced hexagonal water delay the aging process in Drosophila?

Year Published: 2012

No abstract available
HEART - HEART ATTACK (MYOCARDIAL INFARCTION)

Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine

Year Published: 2012

The present study was carried out to determine whether inhalation of hydrogen (H(2)) gas protects myocardium against ischemia-reperfusion (I/R) injury in swine. In anesthetized open-chest swine, myocardial stunning was produced by 12-minute occlusion of left anterior descending coronary artery (LAD) followed by 90-minute reperfusion in the first study. Group A inhaled 100% oxygen, and group B ...
LUNG - SURGERY/TRANSPLANTATION

Hydrogen saline is protective for acute lung ischaemia/reperfusion injuries in rats

Year Published: 2012

Protective effects of saturated hydrogen (H(2)) saline on cardiac ischaemia-reperfusion (I/R) injury have been demonstrated previously. This study was designed to show that hydrogen-rich saline is protective in preventing lung I/R injury in rats. Adult male Sprague-Dawley rats underwent 45 min occlusion of the right lung roots and 120 min reperfusion. Rats were divided randomly into three groups: ...
HEART - ATHEROSCLEROSIS

Hydrogen decreases athero-susceptibility in apolipoprotein B-containing lipoproteins and aorta of ...

Year Published: 2012

It is to characterize the underlying molecular mechanisms of the anti-atherosclerotic effects of hydrogen (dihydrogen; H(2)), a novel antioxidant. In particular, to examine the effects of hydrogen on athero-susceptibility in lipoproteins and aorta of apolipoprotein E knockout (apoE-/-) mice. Plasma analysis by enzymatic method and spectrophotometric measurement showed that eight weeks ...
BRAIN - SEPSIS

Molecular hydrogen reduces LPS-induced neuroinflammation and promotes recovery from sickness ...

Year Published: 2012

Molecular hydrogen has been shown to have neuroprotective effects in mouse models of acute neurodegeneration. The effect was suggested to be mediated by its free-radical scavenger properties. However, it has been shown recently that molecular hydrogen alters gene expression and protein phosphorylation. The aim of this study was to test whether chronic ad libitum consumption of molecular ...
HEART - SURGERY/TRANSPLANTATION

Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats

Year Published: 2012

Aims: Arterialized vein grafts often fail due to intimal hyperplasia. Hydrogen potently protects organs and cells from many insults via its anti-inflammatory and antioxidant properties. We investigated the efficacy of oral administration of hydrogen-rich water (HW) for prevention of intimal hyperplasia. Methods and results: The inferior vena cava was excised, stored in cold Ringer solution for 2 ...
BLOOD - BLOOD COMPOSITION

Hydrogen May Inhibit Collagen-Induced Platelet Aggregation: An ex vivo and in vivo Study

Year Published: 2012

Hydrogen selectively reduces hydroxyl radicals and peroxynitrite, and numerous experimental and clinical studies suggest that hydrogen can exert potent cellular protective effects against a wide variety of diseases. Furthermore, there is increasing evidence that antioxidants can modulate platelet activation. The aim of the present study was to investigate the relationship between hydrogen and ...
LIVER - SURGERY/TRANSPLANTATION

Suppressive Effect of High Hydrogen Generating High Amylose Cornstarch on Subacute Hepatic ...

Year Published: 2012

We examined whether feeding high hydrogen generating resistant starch could suppress subacute hepatic ischemia-reperfusion injury. Rats were fed a control diet with or without 20% high amylose cornstarch (HAS) supplementation for 14 days. On day 12, rats were subject to ischemia-reperfusion treatment. Portal hydrogen concentration was higher in the HAS group compared with the control group. ...
LUNG - SURGERY/TRANSPLANTATION

Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement

Year Published: 2012

We previously demonstrated that donor treatment with inhaled hydrogen protects lung grafts from cold ischemia/reperfusion (I/R) injury during lung transplantation. To elucidate the mechanisms underlying hydrogen's protective effects, we conducted a gene array analysis to identify changes in gene expression associated with hydrogen treatment. Donor rats were exposed to mechanical ventilation with ...
WHOLE BODY - DIABETES

Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model ...

Year Published: 2012

Background: Molecular hydrogen, as a novel antioxidant, has been proven effective in treating many diseases. This study aimed to evaluate the therapeutic effects of hydrogen saturated saline in treatment of a rat model of diabetes mellitus and a rat model of insulin resistant. Methods: A rat diabetes mellitus model was established by feeding a high fat/high carbohydrate diet followed by injection ...
BRAIN - ENVIRONMENTAL POLLUTION

Hydrogen rich saline reduces immune-mediated brain injury in rats with acute carbon monoxide ...

Year Published: 2012

This experiment was designed to determine whether hydrogen (H(2)) rich saline can ameliorate brain abnormalities in a rat model with acute carbon monoxide (CO) poisoning. Sprague-Dawley male rats were used for CO poisoning and H(2) rich saline treatment. Changes in neurons, microglias, and myelin sheath were observed by electron microscope. Neuron loss was assessed by Nissl staining. Antioxidant ...