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Studies Found: 1183

HEART - CARDIOVASCULAR DISEASE (CVD)

Intravenous low redox potential saline attenuates FeCl3-induced vascular dysfunction via ...

Year Published: 2011

Exaggerated reactive oxygen species (ROS) may contribute to vascular injury by the enhancement of CX3CL1, intercellular adhesion molecule-1 (ICAM-1), and pro-apoptotic p53 expression. Reduced water with safely antioxidant activity may protect vascular tissue against oxidative injury. We established reduced water (RW) by using a modified magnesium alloy and evaluated the effects of an RW-made ...
INTESTINE - INTESTINAL INJURY

The Effects of Hydrogen-Rich Saline on the Contractile and Structural Changes of Intestine Induced ...

Year Published: 2011

Background: Hydrogen has been considered as a novel antioxidant that prevents injuries resulted from ischemia-reperfusion (I/R) injury in various tissues. The study was designed to determine the effect of hydrogen-rich saline on the smooth muscle contractile response to KCl, and on epithelial proliferation and apoptosis of intestine subjected to I/R. Methods: Intestinal I/R injury was induced in ...
LUNG - UPPER RESPIRATORY TRACT INFECTION

Effect of acid-electrolyzed water on bacteria of upper respiratory tract infections

Year Published: 2011

People are aware of the importance of health, especially the effect of electrolyzed water. So the market for electrolyzed water-related equipment has increased recently. People only know the importance of alkaline-electrolyzed water to health, but the effects of acid-electrolyzed water are not as well known. In this study, we evaluated the characteristics and functions of acid-electrolyzed water ...
TESTES - RADIOPROTECTION

Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing ...

Year Published: 2011

Our recent studies suggest that H2 (hydrogen) has a potential as a novel radioprotector without known toxic side effects. The present study was designed to examine the underlying radioprotective mechanism of H2 and its protective role on irradiated germ cells. Produced by the Fenton reaction and radiolysis of H2O, hydroxyl radicals (•OH) were identified as the free radical species that were ...
BRAIN - SURGERY/TRANSPLANTATION

Hydrogen is neuroprotective against surgically induced brain injury

Year Published: 2011

Neurosurgical operations cause unavoidable damage to healthy brain tissues. Direct surgical injury as well as surgically induced oxidative stress contributes to the subsequent formation of brain edema. Therefore, we tested the neuroprotective effects of hydrogen (H2) in an established surgical brain injury (SBI) model in rats. Adult male Sprague - Dawley rats (weight 300-350g) were divided into ...
LUNG - LUNG INJURY

Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model

Year Published: 2011

Hydrogen has been reported to selectively quench detrimental reactive oxygen species, particularly hydroxyl radical, and to prevent myocardial or hepatic ischemia/reperfusion injury in multiple models. The aim of this study is to investigate whether hydrogen protects against severe burn-induced acute lung injury in rats. Rats were divided into four groups: sham plus normal saline, burn injury plus ...
MUSCLE - MUSCULAR DYSTROPHY

Effect of Molecular Hydrogen Saturated Alkaline Electrolyzed Water on Disuse Muscle Atrophy in ...

Year Published: 2011

The objectives of this paper were to determine the level of oxidative stress in atrophied gastrocnemius, and to verify the effect of molecular hydrogen (H2) saturated alkaline electrolyzed water (HSW) on gastrocnemius atrophy by modifying the redox status, indicated by 8-hydroxy-2'-deoxyguanosine (8-OHdG), malondialdehyde (MDA), and superoxide dismutase (SOD)-like activity. Female Wistar rats were ...
BONE - ROS-SCAVENGING

Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene ...

Year Published: 2011

Background: Molecular hydrogen (H2) functions as an extensive protector against oxidative stress, inflammation and allergic reaction in various biological models and clinical tests; however, its essential mechanisms remain unknown. H2 directly reacts with the strong reactive nitrogen species peroxynitrite (ONOO-) as well as hydroxyl radicals (•OH), but not with nitric oxide radical (NO•). We ...
KIDNEY - METABOLIC SYNDROME

Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Lepr cp /NDmcr rat - A metabolic ...

Year Published: 2011

Hydrogen (H2), a potent free radical scavenger, selectively reduces the hydroxyl radical, which is the most cytotoxic of the reactive oxygen species (ROS). An increase in oxygen free radicals induces oxidative stress, which is known to be involved in the development of metabolic syndrome. Therefore, we investigated whether hydrogen-rich water (HRW) affects metabolic abnormalities in the metabolic ...
HEART - SLEEP APNEA

Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in ...

Year Published: 2011

Sleep apnea syndrome increases the risk of cardiovascular morbidity and mortality. We previously reported that intermittent hypoxia increases superoxide production in a manner dependent on nicotinamide adenine dinucleotide phosphate and accelerates adverse left ventricular (LV) remodeling. Recent studies have suggested that hydrogen (H(2)) may have an antioxidant effect by reducing hydroxyl ...
LUNG - SURGERY/TRANSPLANTATION

Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism ...

Year Published: 2011

We recently demonstrated the inhalation of hydrogen gas, a novel medical therapeutic gas, ameliorates ventilator-induced lung injury (VILI); however, the molecular mechanisms by which hydrogen ameliorates VILI remain unclear. Therefore, we investigated whether inhaled hydrogen gas modulates the nuclear factor-kappa B (NFκB) signaling pathway. VILI was generated in male C57BL6 mice by performing a ...
EYE - RETINAL INJURY

Hydrogen Saline Treatment Attenuates Hyperoxia-Induced Retinopathy by Inhibition of Oxidative Stress ...

Year Published: 2011

Retinal neovascularization or retinopathy is a proliferative disorder of the retinal capillaries and is the primary cause of blindness. Some studies have shown that oxidative stress plays an important role in hyperoxia-induced retinal neovascularization. Previous reports have indicated that hydrogen has a therapeutic, antioxidant activity by selectively reducing hydroxyl radicals. This study ...
SPINE - PARAPLEGIA

Beneficial effects of hydrogen gas against spinal cord ischemia-reperfusion injury in rabbits

Year Published: 2011

Recently, hydrogen gas (H₂) is reported to be a new therapeutic agent in organ damage induced by ischemia-reperfusion (I/R). The present study was designed to investigate the beneficial effects of H₂ against spinal cord I/R injury and its associated mechanisms. Spinal cord ischemia was induced by infrarenal aortic occlusion for 20 min in male New Zealand white rabbits. Treatment with 1%, 2% or ...
BRAIN - STROKE

Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein ...

Year Published: 2011

Transient global cerebral ischemia (TGCI) occurs during acute severe hypotension depriving the brain of oxygen and glucose for a short period of time. During reperfusion, several mechanisms can induce secondary neuronal damage, including the increased production of reactive oxygen species (ROS). Hydrogen gas-enriched air inhalation is a neuroprotective approach with proven antioxidant potential, ...
MUSCLE - MUSCULAR DYSTROPHY

Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of ...

Year Published: 2011

Background: Molecular hydrogen has prominent effects on more than 30 animal models especially of oxidative stress-mediated diseases and inflammatory diseases. In addition, hydrogen effects on humans have been reported in diabetes mellitus type 2, hemodialysis, metabolic syndrome, radiotherapy for liver cancer, and brain stem infarction. Hydrogen effects are ascribed to specific radical-scavenging ...
BONE - RHEUMATOID ARTHRITIS (RA)

Molecular hydrogen inhibits lipopolysaccharide/interferon γ-induced nitric oxide production through ...

Year Published: 2011

Molecular hydrogen has been reported to be effective for a variety of disorders and its effects have been ascribed to the reduction of oxidative stress. However, we have recently demonstrated that hydrogen inhibits type I allergy through modulating intracellular signal transduction. In the present study, we examined the hydrogen effects on lipopolysaccharide/interferon γ LPS/IFNγ-induced nitric ...
INTESTINE - IRRITABLE BOWEL SYNDROME (IBS)

The effects of methane and hydrogen gases produced by enteric bacteria on ileal motility and colonic ...

Year Published: 2011

Background: Gases produced by intestinal flora may modulate intestinal motor function in healthy individuals as well as those with functional bowel disease. Methane, produced by enteric bacteria in the human gut, is associated with slowed intestinal transit and constipation. The effects of hydrogen, another main gas produced by bacterial fermentation in the gut, on small bowel and colonic motor ...
BRAIN - BRAIN INJURY

The effect of hydrogen-rich saline on the brain of rats with transient ischemia

Year Published: 2011

Background: Due to its antioxidant and anti-inflammatory properties, hydrogen gas (H(2)) has protective effects on a variety of organs from damage induced by ischemia/reperfusion (I/R). In this study, we tested the protective effect of hydrogen-rich saline on the brain in a global cerebral I/R model. Materials and methods: We used a four-vessel occlusion model of global cerebral ischemia (15 min) ...
WHOLE BODY - DIABETES (TYPE II)

Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy ...

Year Published: 2011

Recent extensive studies have revealed that molecular hydrogen (H(2)) has great potential for improving oxidative stress-related diseases by inhaling H(2) gas, injecting saline with dissolved H(2), or drinking water with dissolved H(2) (H(2)-water); however, little is known about the dynamic movement of H(2) in a body. First, we show that hepatic glycogen accumulates H(2) after oral administration ...
LIVER - CANCER

Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy ...

Year Published: 2011

Background: Cancer patients receiving radiotherapy often experience fatigue and impaired quality of life (QOL). Many side effects of radiotherapy are believed to be associated with increased oxidative stress and inflammation due to the generation of reactive oxygen species during radiotherapy. Hydrogen can be administered as a therapeutic medical gas, has antioxidant properties, and reduces ...
MOUTH - PERIODONTITIS

Hydrogen-rich water attenuates experimental periodontitis in a rat model

Year Published: 2011

Reactive oxygen species (ROS) contribute to the development of periodontitis. As molecular hydrogen can act as a scavenger of ROS, we examined the effects of treatment with hydrogen-rich water on a rat model of periodontitis. A ligature was placed around the maxillary molars for 4 weeks to induce periodontitis, and the animals were given drinking water with or without hydrogen-rich water. The rats ...
LUNG - SURGERY/TRANSPLANTATION

The effect of donor treatment with hydrogen on lung allograft function in rats

Year Published: 2011

Because inhaled hydrogen provides potent anti-inflammatory and antiapoptotic effects against acute lung injury, we hypothesized that treatment of organ donors with inhaled hydrogen during mechanical ventilation would decrease graft injury after lung transplantation. Orthotopic left lung transplants were performed using a fully allogeneic Lewis to Brown Norway rat model. The donors were exposed to ...
MOUTH - DENTURE CARE

Cleansing effect of the alkaline ionized water on microorganisms of the denture surface

Year Published: 2011

Purpose: The purpose of this study was to evaluate the cleansing effect of recently developed alkaline ionized water, e-WASH, on microorganisms of the denture surface. Materials and methods: Removable partial and complete dentures were randomly assigned to the experimental group of 41 dentures, and the control group of 26. The denture was immersed in the e-WASH solution (experimental group), or ...
EYE - CORNEAL INJURY

Hydrogen and N-Acetyl-L-Cysteine Rescue Oxidative Stress-Induced Angiogenesis in a Mouse Corneal ...

Year Published: 2011

To investigate the role of reactive oxygen species (ROS) as the prime initiators of the angiogenic response after alkali injury of the cornea and observe the effects of antioxidants in preventing angiogenesis. The corneal epithelia of SOD-1-deficient mice or wild-type (WT) mice were removed after application of 0.15 N NaOH to establish the animal model of alkali burn. ROS production was ...
BRAIN - BRAIN INJURY

Protective Effect of Hydrogen Gas Therapy After Germinal Matrix Hemorrhage in Neonatal Rats

Year Published: 2011

Germinal matrix hemorrhage (GMH) is a neurological disease of very low birth weight premature infants leading to post-hemorrhagic hydrocephalus, cerebral palsy, and mental retardation. Hydrogen (H2) is a potent antioxidant shown to selectively reverse cytotoxic oxygen-radical injury in the brain. This study investigated the therapeutic effect of hydrogen gas after neonatal GMH injury. Neonatal ...